Amlodipine besylateProduct ingredient for Amlodipine
- Name
- Amlodipine besylate
- Drug Entry
- Amlodipine
Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called dihydropyridine calcium channel blockers. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities than other calcium channel blockers 5.
Amlodipine is commonly used in the treatment of high blood pressure and angina. Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), an important vasodilator that decreases blood pressure 3. The option for single daily dosing of amlodipine is an attractive feature of this drug Label.
- Accession Number
- DBSALT001054
- Structure
Structure for Amlodipine besylate (DBSALT001054)
- Synonyms
- amlodipine benzenesulfonate / Amlodipine besilate
- External IDs
- UK-48,340-26 / Uk-48340-26
- UNII
- 864V2Q084H
- CAS Number
- 111470-99-6
- Weight
- Average: 567.05
Monoisotopic: 566.1489648 - Chemical Formula
- C26H31ClN2O8S
- InChI Key
- ZPBWCRDSRKPIDG-UHFFFAOYSA-N
- InChI
- InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
- IUPAC Name
- 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate; benzenesulfonic acid
- SMILES
- OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC
- External Links
- KEGG Drug
- D00615
- ChemSpider
- 54537
- ChEBI
- 2669
- ChEMBL
- CHEMBL1200402
- Wikipedia
- Amlodipine
- Predicted Properties
Property Value Source Water Solubility 0.0074 mg/mL ALOGPS logP 2.22 ALOGPS logP 1.64 Chemaxon logS -4.7 ALOGPS pKa (Strongest Acidic) 19.12 Chemaxon pKa (Strongest Basic) 9.45 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 99.88 Å2 Chemaxon Rotatable Bond Count 11 Chemaxon Refractivity 108.64 m3·mol-1 Chemaxon Polarizability 42.28 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon