Levosalbutamol tartrateProduct ingredient for Levosalbutamol
- Name
- Levosalbutamol tartrate
- Drug Entry
- Levosalbutamol
Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). Salbutamol has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective disposition of salbutamol and the possibility that (S)-salbutamol has adverse effects have led to the development of an enantiomerically pure (R)-salbutamol formulation known as levosalbutamol (levalbuterol).
- Accession Number
- DBSALT001385
- Structure
Structure for Levosalbutamol tartrate (DBSALT001385)
- Synonyms
- Levalbuterol tartrate / Levosalbutamol tartrate
- UNII
- ADS4I3E22M
- CAS Number
- 661464-94-4
- Weight
- Average: 628.716
Monoisotopic: 628.320724994 - Chemical Formula
- C30H48N2O12
- InChI Key
- VNVNZKCCDVFGAP-FPDJQMMJSA-N
- InChI
- InChI=1S/2C13H21NO3.C4H6O6/c2*1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;5-1(3(7)8)2(6)4(9)10/h2*4-6,12,14-17H,7-8H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t2*12-;1-,2-/m001/s1
- IUPAC Name
- (2R,3R)-2,3-dihydroxybutanedioic acid; bis(4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol)
- SMILES
- O[C@H]([C@@H](O)C(O)=O)C(O)=O.CC(C)(C)NC[C@H](O)C1=CC=C(O)C(CO)=C1.CC(C)(C)NC[C@H](O)C1=CC=C(O)C(CO)=C1
- External Links
- ChemSpider
- 8524490
- Predicted Properties
Property Value Source Water Solubility 2.15 mg/mL ALOGPS logP 0.44 ALOGPS logP 0.34 Chemaxon logS -2 ALOGPS pKa (Strongest Acidic) 10.12 Chemaxon pKa (Strongest Basic) 9.4 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 72.72 Å2 Chemaxon Rotatable Bond Count 13 Chemaxon Refractivity 67.87 m3·mol-1 Chemaxon Polarizability 26.85 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon