Mepyramine maleateProduct ingredient for Mepyramine
- Name
- Mepyramine maleate
- Drug Entry
- Mepyramine
Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescription medication used for cough, cold, or allergic conditions.
- Accession Number
- DBSALT001405
- Structure
Structure for Mepyramine maleate (DBSALT001405)
- Synonyms
- Pyrilamine maleate
- UNII
- R35D29L3ZA
- CAS Number
- 59-33-6
- Weight
- Average: 401.463
Monoisotopic: 401.195070981 - Chemical Formula
- C21H27N3O5
- InChI Key
- JXYWFNAQESKDNC-BTJKTKAUSA-N
- InChI
- InChI=1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
- IUPAC Name
- (2Z)-but-2-enedioic acid; N-[2-(dimethylamino)ethyl]-N-[(4-methoxyphenyl)methyl]pyridin-2-amine
- SMILES
- [H]\C(=C(/[H])C(O)=O)C(O)=O.COC1=CC=C(CN(CCN(C)C)C2=CC=CC=N2)C=C1
- External Links
- ChemSpider
- 4447518
- ChEMBL
- CHEMBL1201006
- Wikipedia
- Mepyramine
- Predicted Properties
Property Value Source Water Solubility 0.781 mg/mL ALOGPS logP 2.89 ALOGPS logP 3.04 Chemaxon logS -2.6 ALOGPS pKa (Strongest Basic) 8.76 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 28.6 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 87.74 m3·mol-1 Chemaxon Polarizability 33.07 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon