Levosalbutamol hydrochlorideProduct ingredient for Levosalbutamol
- Name
- Levosalbutamol hydrochloride
- Drug Entry
- Levosalbutamol
Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). Salbutamol has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective disposition of salbutamol and the possibility that (S)-salbutamol has adverse effects have led to the development of an enantiomerically pure (R)-salbutamol formulation known as levosalbutamol (levalbuterol).
- Accession Number
- DBSALT001453
- Structure
Structure for Levosalbutamol hydrochloride (DBSALT001453)
- Synonyms
- Levalbuterol HCl / Levalbuterol hydrochloride / Levosalbutamol HCl / Levosalbutamol hydrochloride
- UNII
- WDQ1526QJM
- CAS Number
- 50293-90-8
- Weight
- Average: 275.77
Monoisotopic: 275.1288213 - Chemical Formula
- C13H22ClNO3
- InChI Key
- OWNWYCOLFIFTLK-YDALLXLXSA-N
- InChI
- InChI=1S/C13H21NO3.ClH/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;/h4-6,12,14-17H,7-8H2,1-3H3;1H/t12-;/m0./s1
- IUPAC Name
- 4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol hydrochloride
- SMILES
- Cl.CC(C)(C)NC[C@H](O)C1=CC(CO)=C(O)C=C1
- External Links
- ChemSpider
- 110193
- ChEMBL
- CHEMBL1201061
- Wikipedia
- Levosalbutamol
- Predicted Properties
Property Value Source Water Solubility 2.15 mg/mL ALOGPS logP 0.44 ALOGPS logP 0.34 Chemaxon logS -2 ALOGPS pKa (Strongest Acidic) 10.12 Chemaxon pKa (Strongest Basic) 9.4 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 72.72 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 67.87 m3·mol-1 Chemaxon Polarizability 26.86 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon