Magnesium pidolateProduct ingredient for Pidolic acid
- Name
- Magnesium pidolate
- Drug Entry
- Pidolic acid
Pidolic acid is a naturally occurring but little-studied amino acid derivative that can be formed enzymatically or non-enzymatically and participates as a biological intermediate with unique pharmacodynamics in various chemical pathways 4,7. Elevations of the acid in blood levels may be associated with problems of glutamine or glutathione metabolism 7. Pidolic acid, in general, is found in large quantities in brain tissue and other tissues in bound form, like skin 7.
There are currently little to no medicines available that are clinically approved or marketed for employing pidolic acid as an active ingredient for any particular formal indication. Although pidolic acid is included in some over-the-counter, non-prescription dietary supplements for the proposed purpose of facilitating cognitive or memory enhancement, most available research suggest exercising caution in their recommendation as much more research is necessary 1,2.
- Accession Number
- DBSALT002689 (DB13301)
- Structure
Structure for Magnesium pidolate (DBSALT002689)
- Synonyms
- Magnesium PCA / Magnesium pyroglutamate
- UNII
- V5PC588N7G
- CAS Number
- 62003-27-4
- Weight
- Average: 280.519
Monoisotopic: 280.05457781 - Chemical Formula
- C10H12MgN2O6
- InChI Key
- JQAACYUZYRBHGG-QHTZZOMLSA-L
- InChI
- InChI=1S/2C5H7NO3.Mg/c2*7-4-2-1-3(6-4)5(8)9;/h2*3H,1-2H2,(H,6,7)(H,8,9);/q;;+2/p-2/t2*3-;/m00./s1
- IUPAC Name
- magnesium(2+) bis((2S)-5-hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylate)
- SMILES
- [Mg++].OC1=N[C@@H](CC1)C([O-])=O.OC1=N[C@@H](CC1)C([O-])=O
- External Links
- PubChem Compound
- 18601084
- PubChem Substance
- 347829291
- ChemSpider
- 18555951
- ChEMBL
- CHEMBL3707303
- Wikipedia
- Magnesium_pidolate
- Predicted Properties
Property Value Source Water Solubility 0.858 mg/mL ALOGPS logP 0.07 ALOGPS logP -0.07 Chemaxon logS -2.5 ALOGPS pKa (Strongest Acidic) 3.63 Chemaxon pKa (Strongest Basic) 1 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 72.72 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 39.45 m3·mol-1 Chemaxon Polarizability 11.21 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon