Cytochrome P450 1A2

Details

Name
Cytochrome P450 1A2
Synonyms
  • 1.14.14.1
  • Cholesterol 25-hydroxylase
  • CYPIA2
  • Cytochrome P(3)450
  • Cytochrome P450 4
  • Cytochrome P450-P3
Gene Name
CYP1A2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0004778|Cytochrome P450 1A2
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG
QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM
AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN
LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS
DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL
WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE
FSVPPGVKVDLTPIYGLTMKHARCEHVQARRFSIN
Number of residues
515
Molecular Weight
58293.76
Theoretical pI
9.43
GO Classification
Functions
aromatase activity / caffeine oxidase activity / demethylase activity / electron carrier activity / enzyme binding / heme binding / iron ion binding / monooxygenase activity / oxidoreductase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Processes
alkaloid metabolic process / arachidonic acid metabolic process / cellular respiration / cellular response to cadmium ion / dibenzo-p-dioxin metabolic process / drug catabolic process / drug metabolic process / epoxygenase P450 pathway / exogenous drug catabolic process / heterocycle metabolic process / hydrogen peroxide biosynthetic process / lung development / methylation / monocarboxylic acid metabolic process / monoterpenoid metabolic process / omega-hydroxylase P450 pathway / oxidation-reduction process / oxidative deethylation / oxidative demethylation / porphyrin-containing compound metabolic process / post-embryonic development / regulation of gene expression / response to estradiol / response to immobilization stress / response to lipopolysaccharide / small molecule metabolic process / steroid catabolic process / toxin biosynthetic process / xenobiotic metabolic process
Components
endoplasmic reticulum membrane / intracellular membrane-bounded organelle
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0011742|Cytochrome P450 1A2 (CYP1A2)
ATGGCATTGTCCCAGTCTGTTCCCTTCTCGGCCACAGAGCTTCTCCTGGCCTCTGCCATC
TTCTGCCTGGTATTCTGGGTGCTCAAGGGTTTGAGGCCTCGGGTCCCCAAAGGCCTGAAA
AGTCCACCAGAGCCATGGGGCTGGCCCTTGCTCGGGCATGTGCTGACCCTGGGGAAGAAC
CCGCACCTGGCACTGTCAAGGATGAGCCAGCGCTACGGGGACGTCCTGCAGATCCGCATT
GGCTCCACGCCCGTGCTGGTGCTGAGCCGCCTGGACACCATCCGGCAGGCCCTGGTGCGG
CAGGGCGACGATTTCAAGGGCCGGCCTGACCTCTACACCTCCACCCTCATCACTGATGGC
CAGAGCTTGACCTTCAGCACAGACTCTGGACCGGTGTGGGCTGCCCGCCGGCGCCTGGCC
CAGAATGCCCTCAACACCTTCTCCATCGCCTCTGACCCAGCTTCCTCATCCTCCTGCTAC
CTGGAGGAGCATGTGAGCAAGGAGGCTAAGGCCCTGATCAGCAGGTTGCAGGAGCTGATG
GCAGGGCCTGGGCACTTCGACCCTTACAATCAGGTGGTGGTGTCAGTGGCCAACGTCATT
GGTGCCATGTGCTTCGGACAGCACTTCCCTGAGAGTAGCGATGAGATGCTCAGCCTCGTG
AAGAACACTCATGAGTTCGTGGAGACTGCCTCCTCCGGGAACCCCCTGGACTTCTTCCCC
ATCCTTCGCTACCTGCCTAACCCTGCCCTGCAGAGGTTCAAGGCCTTCAACCAGAGGTTC
CTGTGGTTCCTGCAGAAAACAGTCCAGGAGCACTATCAGGACTTTGACAAGAACAGTGTC
CGGGACATCACGGGTGCCCTGTTCAAGCACAGCAAGAAGGGGCCTAGAGCCAGCGGCAAC
CTCATCCCACAGGAGAAGATTGTCAACCTTGTCAATGACATCTTTGGAGCAGGATTTGAC
ACAGTCACCACAGCCATCTCCTGGAGCCTCATGTACCTTGTGACCAAGCCTGAGATACAG
AGGAAGATCCAGAAGGAGCTGGACACTGTGATTGGCAGGGAGCGGCGGCCCCGGCTCTCT
GACAGACCCCAGCTGCCCTACTTGGAGGCCTTCATCCTGGAGACCTTCCGACACTCCTCC
TTCTTGCCCTTCACCATCCCCCACAGCACAACAAGGGACACAACGCTGAATGGCTTCTAC
ATCCCCAAGAAATGCTGTGTCTTCGTAAACCAGTGGCAGGTCAACCATGACCCAGAGCTG
TGGGAGGACCCCTCTGAGTTCCGGCCTGAGCGGTTCCTCACCGCCGATGGCACTGCCATT
AACAAGCCCTTGAGTGAGAAGATGATGCTGTTTGGCATGGGCAAGCGCCGGTGTATCGGG
GAAGTCCTGGCCAAGTGGGAGATCTTCCTCTTCCTGGCCATCCTGCTACAGCAACTGGAG
TTCAGCGTGCCGCCGGGCGTGAAAGTCGACCTGACCCCCATCTACGGGCTGACCATGAAG
CACGCCCGCTGTGAACATGTCCAGGCGCGGCTGCGCTTCTCCATCAATTGA
Chromosome Location
15
Locus
15q24
External Identifiers
ResourceLink
UniProtKB IDP05177
UniProtKB Entry NameCP1A2_HUMAN
GenBank Gene IDZ00036
GenAtlas IDCYP1A2
HGNC IDHGNC:2596
General References
  1. Jaiswal AK, Nebert DW, Gonzalez FJ: Human P3(450): cDNA and complete amino acid sequence. Nucleic Acids Res. 1986 Aug 26;14(16):6773-4. [Article]
  2. Quattrochi LC, Pendurthi UR, Okino ST, Potenza C, Tukey RH: Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6731-5. [Article]
  3. Ikeya K, Jaiswal AK, Owens RA, Jones JE, Nebert DW, Kimura S: Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression. Mol Endocrinol. 1989 Sep;3(9):1399-408. [Article]
  4. Jaiswal AK, Nebert DW, McBride OW, Gonzalez FJ: Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15. J Exp Pathol. 1987 Winter;3(1):1-17. [Article]
  5. Corchero J, Pimprale S, Kimura S, Gonzalez FJ: Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation. Pharmacogenetics. 2001 Feb;11(1):1-6. [Article]
  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  7. Wrighton SA, Campanile C, Thomas PE, Maines SL, Watkins PB, Parker G, Mendez-Picon G, Haniu M, Shively JE, Levin W, et al.: Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat. Mol Pharmacol. 1986 Apr;29(4):405-10. [Article]
  8. Quattrochi LC, Okino ST, Pendurthi UR, Tukey RH: Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6. DNA. 1985 Oct;4(5):395-400. [Article]
  9. Zhou H, Josephy PD, Kim D, Guengerich FP: Functional characterization of four allelic variants of human cytochrome P450 1A2. Arch Biochem Biophys. 2004 Feb 1;422(1):23-30. [Article]
  10. Honda A, Miyazaki T, Ikegami T, Iwamoto J, Maeda T, Hirayama T, Saito Y, Teramoto T, Matsuzaki Y: Cholesterol 25-hydroxylation activity of CYP3A. J Lipid Res. 2011 Aug;52(8):1509-16. doi: 10.1194/jlr.M014084. Epub 2011 May 16. [Article]
  11. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  12. Sansen S, Yano JK, Reynald RL, Schoch GA, Griffin KJ, Stout CD, Johnson EF: Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2. J Biol Chem. 2007 May 11;282(19):14348-55. Epub 2007 Feb 20. [Article]
  13. Huang JD, Guo WC, Lai MD, Guo YL, Lambert GH: Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese. Drug Metab Dispos. 1999 Jan;27(1):98-101. [Article]
  14. Chevalier D, Cauffiez C, Allorge D, Lo-Guidice JM, Lhermitte M, Lafitte JJ, Broly F: Five novel natural allelic variants-951A>C, 1042G>A (D348N), 1156A>T (I386F), 1217G>A (C406Y) and 1291C>T (C431Y)-of the human CYP1A2 gene in a French Caucasian population. Hum Mutat. 2001 Apr;17(4):355-6. [Article]
  15. Murayama N, Soyama A, Saito Y, Nakajima Y, Komamura K, Ueno K, Kamakura S, Kitakaze M, Kimura H, Goto Y, Saitoh O, Katoh M, Ohnuma T, Kawai M, Sugai K, Ohtsuki T, Suzuki C, Minami N, Ozawa S, Sawada J: Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes. J Pharmacol Exp Ther. 2004 Jan;308(1):300-6. Epub 2003 Oct 16. [Article]
  16. Solus JF, Arietta BJ, Harris JR, Sexton DP, Steward JQ, McMunn C, Ihrie P, Mehall JM, Edwards TL, Dawson EP: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. Pharmacogenomics. 2004 Oct;5(7):895-931. [Article]
  17. Soyama A, Saito Y, Hanioka N, Maekawa K, Komamura K, Kamakura S, Kitakaze M, Tomoike H, Ueno K, Goto Y, Kimura H, Katoh M, Sugai K, Saitoh O, Kawai M, Ohnuma T, Ohtsuki T, Suzuki C, Minami N, Kamatani N, Ozawa S, Sawada J: Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population. Drug Metab Pharmacokinet. 2005 Feb;20(1):24-33. [Article]
  18. Jiang Z, Dalton TP, Jin L, Wang B, Tsuneoka Y, Shertzer HG, Deka R, Nebert DW: Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus. Hum Mutat. 2005 Feb;25(2):196-206. [Article]
  19. Cornelis MC, El-Sohemy A, Kabagambe EK, Campos H: Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA. 2006 Mar 8;295(10):1135-41. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00176Fluvoxamineapproved, investigationalunknownsubstrateinhibitorDetails
DB00188Bortezomibapproved, investigationalnosubstrateinhibitorDetails
DB00201CaffeineapprovedunknownsubstrateinhibitorDetails
DB00261AnagrelideapprovedunknownsubstrateinhibitorDetails
DB00268Ropiniroleapproved, investigationalunknownsubstrateDetails
DB00277TheophyllineapprovedunknownsubstrateDetails
DB00281Lidocaineapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00286Conjugated estrogensapprovedunknownsubstrateinhibitorDetails
DB00296RopivacaineapprovednosubstrateDetails
DB00315Zolmitriptanapproved, investigationalnosubstrateDetails
DB00316AcetaminophenapprovedunknownsubstrateDetails
DB00321AmitriptylineapprovedunknownsubstrateDetails
DB00334Olanzapineapproved, investigationalnosubstrateDetails
DB00363ClozapineapprovednosubstrateDetails
DB00365Grepafloxacinapproved, investigational, withdrawnunknownsubstrateinhibitorDetails
DB00370MirtazapineapprovedunknownsubstrateDetails
DB00379Mexiletineapproved, investigationalunknownsubstrateinhibitorDetails
DB00382Tacrineapproved, investigational, withdrawnunknownsubstrateDetails
DB00458ImipramineapprovedunknownsubstrateinhibitorDetails
DB00476DuloxetineapprovedunknownsubstrateinhibitorDetails
DB00499Flutamideapproved, investigationalunknownsubstrateDetails
DB00502HaloperidolapprovedunknownsubstrateDetails
DB00537Ciprofloxacinapproved, investigationalunknowninhibitorDetails
DB00540NortriptylineapprovedunknownsubstrateDetails
DB00544FluorouracilapprovedunknownsubstrateDetails
DB00571Propranololapproved, investigationalunknownsubstrateDetails
DB00655EstroneapprovedunknownsubstrateDetails
DB00661VerapamilapprovedunknownsubstrateDetails
DB00682WarfarinapprovedunknownsubstrateDetails
DB00697Tizanidineapproved, investigationalunknownsubstrateDetails
DB00740Riluzoleapproved, investigationalunknownsubstrateDetails
DB00744Zileutonapproved, investigational, withdrawnunknownsubstrateinhibitorDetails
DB00783Estradiolapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00851Dacarbazineapproved, investigationalunknownsubstrateDetails
DB00863Ranitidineapproved, withdrawnunknownsubstrateinhibitorDetails
DB00904Ondansetronapproved, withdrawnunknownsubstrateinhibitorDetails
DB00924CyclobenzaprineapprovedunknownsubstrateDetails
DB00978Lomefloxacinapproved, investigationalunknownsubstrateinhibitorDetails
DB00980Ramelteonapproved, investigationalunknownsubstrateDetails
DB00998Frovatriptanapproved, investigationalunknownsubstrateDetails
DB01002Levobupivacaineapproved, investigationalunknownsubstrateDetails
DB01012CinacalcetapprovedunknownsubstrateDetails
DB01094HesperetinexperimentalunknownsubstrateDetails
DB01097Leflunomideapproved, investigationalunknownsubstrateDetails
DB01100PimozideapprovedunknownsubstrateDetails
DB01165OfloxacinapprovedunknowninhibitorDetails
DB01182PropafenoneapprovedunknownsubstrateinhibitorDetails
DB01242Clomipramineapproved, investigational, vet_approvednosubstrateDetails
DB00969Alosetronapproved, withdrawnunknownsubstrateinhibitorDetails
DB01367RasagilineapprovedunknownsubstrateDetails
DB00356ChlorzoxazoneapprovedunknownsubstrateDetails
DB00467Enoxacinapproved, investigationalunknowninhibitorDetails
DB00477Chlorpromazineapproved, investigational, vet_approvedunknownsubstrateDetails
DB00487PefloxacinapprovedunknowninhibitorDetails
DB00501Cimetidineapproved, investigationalunknowninhibitorDetails
DB00532Mephenytoinapproved, investigational, withdrawnunknownsubstrateDetails
DB00533Rofecoxibapproved, investigational, withdrawnunknownsubstrateinhibitorDetails
DB00586Diclofenacapproved, vet_approvedunknownsubstrateDetails
DB00730Thiabendazoleapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00908Quinidineapproved, investigationalunknowninhibitorDetails
DB00972AzelastineapprovedunknownsubstrateDetails
DB01026Ketoconazoleapproved, investigationalunknowninhibitorDetails
DB01045RifampicinapprovedunknowninducerDetails
DB01059NorfloxacinapprovedunknowninhibitorDetails
DB01418Acenocoumarolapproved, investigationalunknownsubstrateDetails
DB01424Aminophenazoneapproved, withdrawnunknownsubstrateDetails
DB00377Palonosetronapproved, investigationalunknownsubstrateDetails
DB05708GTS-21investigationalunknownsubstrateDetails
DB06442AvasimibeinvestigationalunknowninhibitorDetails
DB01065Melatoninapproved, nutraceutical, vet_approvedunknownsubstrateDetails
DB01115NifedipineapprovedunknownsubstrateinhibitorDetails
DB00619ImatinibapprovednosubstrateDetails
DB00468QuinineapprovedunknownsubstrateDetails
DB01142Doxepinapproved, investigationalnosubstrateDetails
DB00564Carbamazepineapproved, investigationalunknowninhibitorinducerDetails
DB00425ZolpidemapprovedunknownsubstrateDetails
DB00951Isoniazidapproved, investigationalunknowninhibitorDetails
DB00472Fluoxetineapproved, vet_approvedunknownsubstrateinhibitorDetails
DB01435Antipyrineapproved, investigationalunknownsubstrateDetails
DB01118Amiodaroneapproved, investigationalunknowninhibitorDetails
DB00857Terbinafineapproved, investigational, vet_approvedunknownsubstrateDetails
DB00568Cinnarizineapproved, investigationalunknownsubstrateDetails
DB04841FlunarizineapprovedunknownsubstrateDetails
DB00788Naproxenapproved, vet_approvedunknownsubstrateDetails
DB03783PhenacetinwithdrawnunknownsubstrateDetails
DB00553MethoxsalenapprovedunknowninhibitorDetails
DB01388Mibefradilinvestigational, withdrawnunknowninhibitorDetails
DB00745Modafinilapproved, investigationalunknowninducerDetails
DB00607Nafcillinapproved, investigationalunknowninducerDetails
DB06732beta-NaphthoflavoneexperimentalunknowninducerDetails
DB00338Omeprazoleapproved, investigational, vet_approvedunknowninducerDetails
DB01223AminophyllineapprovedunknownsubstrateDetails
DB06216AsenapineapprovedunknownsubstrateDetails
DB00195Betaxololapproved, investigationalunknownsubstrateDetails
DB04574Estrone sulfateapprovedunknownsubstrateDetails
DB00629Guanabenzapproved, investigationalunknownsubstrateDetails
DB01623ThiothixeneapprovedunknownsubstrateDetails
DB00831Trifluoperazineapproved, investigationalunknownsubstrateDetails
DB01174Phenobarbitalapproved, investigationalnoinducerDetails
DB01241GemfibrozilapprovedunknowninhibitorDetails
DB00752Tranylcypromineapproved, investigationalunknowninhibitorDetails
DB01087PrimaquineapprovedunknownsubstrateinducerDetails
DB00758ClopidogrelapprovednosubstrateDetails
DB00420Promazineapproved, vet_approvedunknownsubstrateinhibitorDetails
DB01136Carvedilolapproved, investigationalunknownsubstrateDetails
DB01628Etoricoxibapproved, investigationalunknownsubstrateDetails
DB01645GenisteininvestigationalunknownsubstrateinhibitorDetails
DB07453alpha-NaphthoflavoneexperimentalunknownDetails
DB02709ResveratrolinvestigationalnosubstrateinhibitorinducerDetails
DB00518Albendazoleapproved, vet_approvedunknowninducerDetails
DB01558Bromazepamapproved, illicit, investigationalunknownsubstrateDetails
DB00215CitalopramapprovednoinhibitorDetails
DB01151Desipramineapproved, investigationalunknownproduct ofDetails
DB01191Dexfenfluramineapproved, illicit, investigational, withdrawnunknownsubstrateDetails
DB01184Domperidoneapproved, investigational, vet_approvedunknownsubstrateDetails
DB00625Efavirenzapproved, investigationalunknownsubstrateinhibitorDetails
DB00898EthanolapprovedunknownsubstrateDetails
DB00773EtoposideapprovedunknownsubstrateDetails
DB00400Griseofulvinapproved, investigational, vet_approvedunknowninducerDetails
DB01283Lumiracoxibapproved, investigationalunknownsubstrateDetails
DB00772Malathionapproved, investigationalunknownsubstrateDetails
DB00934Maprotilineapproved, investigationalunknownsubstrateDetails
DB00170Menadioneapproved, nutraceuticalunknowninhibitorinducerDetails
DB00333MethadoneapprovedunknownsubstrateDetails
DB01028Methoxyfluraneapproved, investigational, vet_approved, withdrawnunknownsubstrateDetails
DB06148Mianserinapproved, investigationalunknownsubstrateDetails
DB00184NicotineapprovedunknownsubstrateinducerDetails
DB00806Pentoxifyllineapproved, investigationalunknownsubstrateDetails
DB00850PerphenazineapprovedunknownsubstrateDetails
DB00388PhenylephrineapprovedunknowninducerDetails
DB01058Praziquantelapproved, investigational, vet_approvednosubstrateDetails
DB00818Propofolapproved, investigational, vet_approvedunknowninhibitorDetails
DB01129Rabeprazoleapproved, investigationalunknowninhibitorinducerDetails
DB00503Ritonavirapproved, investigationalunknowninducerDetails
DB00412Rosiglitazoneapproved, investigationalunknowninhibitorDetails
DB01037Selegilineapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB01079Tegaserodapproved, investigational, withdrawnunknowninhibitorDetails
DB01405TemafloxacinwithdrawnunknownsubstrateinhibitorDetails
DB01412TheobromineinvestigationalunknownsubstrateDetails
DB00763MethimazoleapprovedunknowninhibitorDetails
DB00208TiclopidineapprovedunknowninhibitorDetails
DB06264TolperisoneinvestigationalunknownsubstrateDetails
DB00384TriamtereneapprovedunknownsubstrateDetails
DB00313Valproic acidapproved, investigationalunknowninhibitorDetails
DB00549Zafirlukastapproved, investigationalunknowninhibitorDetails
DB01303OxtriphyllineapprovedunknownsubstrateDetails
DB00398Sorafenibapproved, investigationalunknownsubstrateDetails
DB00418Secobarbitalapproved, vet_approvedunknowninducerDetails
DB00530Erlotinibapproved, investigationalunknownsubstrateDetails
DB01166Cilostazolapproved, investigationalunknownsubstrateDetails
DB01254Dasatinibapproved, investigationalunknownsubstrateDetails
DB06210EltrombopagapprovedunknownsubstrateDetails
DB06413Armodafinilapproved, investigationalunknowninducerDetails
DB00575ClonidineapprovedunknownsubstrateDetails
DB06594Agomelatineapproved, investigationalunknownsubstrateDetails
DB06510MuraglitazarinvestigationalunknownsubstrateDetails
DB06770Benzyl alcoholapprovedunknownsubstrateDetails
DB06774CapsaicinapprovedunknownsubstrateinducerDetails
DB00633Dexmedetomidineapproved, vet_approvedunknowninhibitorDetails
DB06235VadimezaninvestigationalunknownsubstrateDetails
DB00461NabumetoneapprovedunknownsubstrateDetails
DB06803Niclosamideapproved, investigational, vet_approvedunknowninhibitorDetails
DB00435Nitric OxideapprovedunknowninhibitorDetails
DB06820SulconazoleapprovedunknowninhibitorDetails
DB00428Streptozocinapproved, investigationalunknowninducerDetails
DB06589PazopanibapprovedunknownsubstrateDetails
DB08867UlipristalapprovednosubstrateDetails
DB04871Lorcaserinapproved, withdrawnnosubstrateDetails
DB08881VemurafenibapprovedunknowninhibitorDetails
DB06605ApixabanapprovedunknownsubstrateDetails
DB06626Axitinibapproved, investigationalnosubstrateDetails
DB08910PomalidomideapprovedunknownsubstrateDetails
DB06290SimeprevirapprovednoinhibitorDetails
DB06292DapagliflozinapprovednosubstrateDetails
DB00951Isoniazidapproved, investigationalunknownDetails
DB05812AbirateroneapprovedunknowninhibitorDetails
DB09570Ixazomibapproved, investigationalunknownsubstrateDetails
DB09330OsimertinibapprovednoinducerDetails
DB06769Bendamustineapproved, investigationalnosubstrateDetails
DB00105Interferon alfa-2bapprovedunknowninhibitorDetails
DB05990Obeticholic acidapprovedunknowninhibitordownregulatorDetails
DB01173OrphenadrineapprovedunknowninhibitorDetails
DB00715Paroxetineapproved, investigationalunknownsubstrateinhibitorDetails
DB00008Peginterferon alfa-2aapproved, investigationalunknowninhibitorDetails
DB00022Peginterferon alfa-2bapprovedunknowninhibitorDetails
DB12332Rucaparibapproved, investigationalnosubstrateinhibitorinducerDetails
DB11737Icotinibexperimental, investigationalunknownsubstrateDetails
DB12161Deutetrabenazineapproved, investigationalnosubstrateDetails
DB06595Midostaurinapproved, investigationalunknowninhibitorinducerDetails
DB05015Belinostatapproved, investigationalunknowninducerDetails
DB13174RheinexperimentalunknowninhibitorDetails
DB11994Diacereinapproved, investigationalunknowninhibitorDetails
DB09120Zucapsaicinapproved, investigationalunknowninhibitorDetails
DB09118StiripentolapprovedunknownsubstrateinhibitorinducerDetails
DB09198LobeglitazoneexperimentalnoinhibitorDetails
DB09167DosulepinapprovedunknowninhibitorDetails
DB12026Voxilaprevirapproved, investigationalnosubstrateDetails
DB13874Enasidenibapproved, investigationalunknownsubstrateinhibitorDetails
DB13952Estradiol acetateapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB13953Estradiol benzoateapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB13954Estradiol cypionateapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB13955Estradiol dienanthateapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB13956Estradiol valerateapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB09225Zotepineapproved, investigational, withdrawnnosubstrateDetails
DB11642Pitolisantapproved, investigationalunknowninducerDetails
DB13975Black cohoshexperimentalnoinhibitorDetails
DB14009Medical Cannabisexperimental, investigationalunknownsubstrateinhibitorinducerDetails
DB11198Peppermint oilapproved, investigationalunknowninhibitorDetails
DB04948Lofexidineapproved, investigationalnosubstrateDetails
DB11672Curcuminapproved, investigationalunknowninhibitorDetails
DB00238NevirapineapprovedunknowninhibitorDetails
DB11967Binimetinibapproved, investigationalnosubstrateDetails
DB06654Safinamideapproved, investigationalunknowninhibitorDetails
DB08883PerampanelapprovedunknownsubstrateDetails
DB09078Lenvatinibapproved, investigationalunknowninhibitorDetails
DB05928DovitinibinvestigationalunknowninducerDetails
DB08496(R)-warfarinexperimentalunknownsubstrateDetails
DB141328-chlorotheophyllineexperimentalnosubstrateDetails
DB01320Fosphenytoinapproved, investigationalunknowninducerDetails
DB00993AzathioprineapprovednosubstrateDetails
DB14029FurafyllineexperimentalnoinhibitorDetails
DB04076HypoxanthineexperimentalnosubstrateDetails
DB12406LisofyllineinvestigationalnosubstrateDetails
DB02134XanthineexperimentalnosubstrateDetails
DB06771BesifloxacinapprovednoinhibitorDetails
DB00827Cinoxacinapproved, investigational, withdrawnnoinhibitorDetails
DB11511Difloxacinvet_approvednoinhibitorDetails
DB06160GarenoxacininvestigationalnoinhibitorDetails
DB01044Gatifloxacinapproved, investigational, withdrawnnoinhibitorDetails
DB01155Gemifloxacinapproved, investigationalnoinhibitorDetails
DB00218Moxifloxacinapproved, investigationalnoinhibitorDetails
DB06600NemonoxacininvestigationalnoinhibitorDetails
DB11443Orbifloxacinvet_approvednoinhibitorDetails
DB11774PazufloxacininvestigationalnoinhibitorDetails
DB13823Pipemidic acidexperimentalnoinhibitorDetails
DB11892PrulifloxacininvestigationalnoinhibitorDetails
DB00817Rosoxacinapproved, investigationalnoinhibitorDetails
DB13772RufloxacinexperimentalnoinhibitorDetails
DB11491Sarafloxacinvet_approved, withdrawnnoinhibitorDetails
DB13261Sitafloxacinexperimental, investigationalnoinhibitorDetails
DB01208Sparfloxacinapproved, investigational, withdrawnunknowninhibitorDetails
DB05488Technetium Tc-99m ciprofloxacininvestigationalnoinhibitorDetails
DB00685Trovafloxacinapproved, investigational, withdrawnnoinhibitorDetails
DB016678-azaguanineexperimentalnosubstrateDetails
DB043569-DeazaguanineexperimentalnosubstrateDetails
DB024899-MethylguanineexperimentalnosubstrateDetails
DB13573AcefyllineexperimentalnosubstrateDetails
DB13203BamifyllineexperimentalnosubstrateDetails
DB14018BromotheophyllineapprovednosubstrateDetails
DB13812BufyllineexperimentalnosubstrateDetails
DB09273DoxofyllineexperimentalnosubstrateDetails
DB13592EtamiphyllineexperimentalnosubstrateDetails
DB01482FenethyllineexperimentalnosubstrateDetails
DB13634PentifyllineexperimentalnosubstrateDetails
DB06479PropentofyllineinvestigationalunknownsubstrateDetails
DB13449ProxyphyllineexperimentalnosubstrateDetails
DB09256Tegafurapproved, investigationalunknownsubstrateDetails
DB09288PropacetamolexperimentalnosubstrateDetails
DB14635Curcumin sulfateexperimentalunknowninhibitorDetails
DB00280DisopyramideapprovedunknownsubstrateDetails
DB00454MeperidineapprovedunknowninducerDetails
DB09290RamosetroninvestigationalunknownsubstrateDetails
DB09071Tasimelteonapproved, investigationalunknownsubstrateDetails
DB04951Pirfenidoneapproved, investigationalunknownsubstrateinhibitorDetails
DB12945Dihydralazineapproved, experimentalunknownsubstrateinhibitorDetails
DB11450Pimobendanvet_approvedunknownsubstrateDetails
DB08880TeriflunomideapprovedunknowninducerDetails
DB01609Deferasiroxapproved, investigationalunknowninhibitorDetails
DB08972FlumequinewithdrawnunknowninhibitorDetails
DB14025ClinafloxacininvestigationalunknowninhibitorDetails
DB11753Rifamycinapproved, investigationalnoinhibitorDetails
DB01056TocainideapprovednosubstrateinhibitorDetails
DB09185Viloxazineapproved, investigational, withdrawnnoinhibitorDetails
DB12245Triclabendazoleapproved, investigationalunknownsubstrateinhibitorDetails
DB00455Loratadineapproved, investigationalunknownsubstrateDetails
DB05676Apremilastapproved, investigationalunknownsubstrateDetails
DB11404Enrofloxacinvet_approvedunknowninhibitorDetails
DB00779Nalidixic acidapproved, investigationalunknowninhibitorDetails
DB05396Albinterferon Alfa-2BinvestigationalunknowninhibitorDetails
DB12814Cepeginterferon alfa-2BinvestigationalunknowninhibitorDetails
DB15119Ropeginterferon alfa-2bapproved, investigationalnoinhibitorDetails
DB09122Peginterferon beta-1aapprovedunknowndownregulatorDetails
DB00033Interferon gamma-1bapproved, investigationalunknowninhibitorDetails
DB00068Interferon beta-1bapprovedunknowninhibitorDetails
DB00060Interferon beta-1aapproved, investigationalunknowninhibitorDetails
DB00069Interferon alfacon-1approved, investigationalunknowninhibitorDetails
DB00018Interferon alfa-n3approved, investigationalunknowninhibitorDetails
DB00011Interferon alfa-n1approved, investigationalunknowninhibitorDetails
DB15131Interferon alfa-2cinvestigationalunknowninhibitorDetails
DB00034Interferon alfa-2aapproved, investigationalunknowninhibitorDetails
DB05258Interferon alfainvestigationalunknowninhibitorDetails
DB14999Human interferon betaapproved, investigationalunknowndownregulatorDetails
DB01306Insulin aspartapprovedunknowninducerDetails
DB09456Insulin beefapprovedunknowninducerDetails
DB09564Insulin degludecapprovednoinducerDetails
DB01307Insulin detemirapprovednoinducerDetails
DB00047Insulin glargineapprovedunknowninducerDetails
DB01309Insulin glulisineapprovedunknowninducerDetails
DB00030Insulin humanapproved, investigationalunknowninducerDetails
DB00046Insulin lisproapprovedunknowninducerDetails
DB11567Insulin peglisproinvestigationalunknowninducerDetails
DB00071Insulin porkapprovedunknowninducerDetails
DB05115NN344investigationalunknowninducerDetails
DB11568Insulin tregopilinvestigationalunknowninducerDetails
DB00675TamoxifenapprovedunknownsubstrateDetails
DB11757Istradefyllineapproved, investigationalunknownsubstrateDetails
DB01233Metoclopramideapproved, investigationalunknownsubstrateDetails
DB04889BicifadineinvestigationalunknownsubstrateDetails
DB09061Cannabidiolapproved, investigationalunknowninhibitorDetails
DB14011NabiximolsinvestigationalunknowninhibitorDetails
DB01217Anastrozoleapproved, investigationalunknowninhibitorDetails
DB01195Flecainideapproved, withdrawnunknownsubstrateDetails
DB12001Abemaciclibapproved, investigationalunknowninhibitorDetails
DB01072Atazanavirapproved, investigationalunknowninhibitorDetails
DB15444Elexacaftorapproved, investigationalnoinhibitorDetails
DB00717NorethisteroneapprovedunknownsubstrateDetails
DB06077Lumateperoneapproved, investigationalnosubstrateDetails
DB00252Phenytoinapproved, vet_approvednoinducerDetails
DB00794Primidoneapproved, vet_approvedunknowninducerDetails
DB00927FamotidineapprovednoinhibitorDetails
DB00977EthinylestradiolapprovedunknownsubstrateDetails
DB00440Trimethoprimapproved, vet_approvedunknownsubstrateDetails
DB13609UmifenovirinvestigationalunknownsubstrateDetails
DB01601LopinavirapprovedunknownsubstrateinhibitorDetails
DB11837Osilodrostatapproved, investigationalunknowninhibitorDetails
DB09241Methylene blueapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB11689Selumetinibapproved, investigationalnosubstrateDetails
DB11791Capmatinibapproved, investigationalunknowninhibitorDetails
DB00574Fenfluramineapproved, illicit, investigational, withdrawnunknownsubstrateDetails
DB00409Remoxiprideapproved, withdrawnunknowninhibitorDetails
DB11932Abametapirapproved, investigationalnosubstrateinhibitorDetails
DB12499Clascoteroneapproved, investigationalnoinhibitorDetails
DB15093Somapacitanapproved, investigationalunknowninducerDetails
DB15822Pralsetinibapproved, investigationalnosubstrateDetails
DB06448Lonafarnibapproved, investigationalnosubstrateDetails
DB06137Tirbanibulinapproved, investigationalnoinhibitorDetails
DB08912Dabrafenibapproved, investigationalnoinhibitorDetails
DB11632Opicaponeapproved, investigationalnoinhibitorDetails
DB00784Mefenamic acidapprovedunknownsubstrateinhibitorDetails
DB00052Somatotropinapproved, investigationalunknowninducerDetails
DB00330EthambutolapprovedunknowninhibitorDetails
DB15442Trilaciclibapproved, investigationalunknowninducerDetails
DB14989Umbralisibapproved, investigational, withdrawnunknownsubstrateDetails
DB04854FebuxostatapprovednosubstrateDetails
DB01086Benzocaineapproved, investigationalunknownsubstrateDetails
DB11564Insulin argineexperimentalunknowninducerDetails
DB01381Ginkgo bilobaapproved, investigational, nutraceuticalnoinhibitorDetails
DB00986Glycopyrroniumapproved, investigational, vet_approvedunknownsubstrateDetails
DB12151Brincidofovirapproved, investigationalnoinhibitorDetails
DB16703Belumosudilapproved, investigationalnoinhibitorDetails
DB12265Fexinidazoleapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB16220Lonapegsomatropinapproved, investigationalunknowninducerDetails
DB15011Avacopanapproved, investigationalnoinducerDetails
DB06234Maribavirapproved, investigationalnosubstrateDetails
DB04216Quercetinexperimental, investigationalnoinhibitorDetails
DB05667Levoketoconazoleapproved, investigationalnoinducerDetails
DB16236Mitapivatapproved, investigationalnosubstrateDetails
DB09061Cannabidiolapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00470Dronabinolapproved, illicitnoinhibitorDetails
DB14737Cannabinolexperimental, investigationalunknowninhibitorDetails
DB11697Pacritinibapproved, investigationalnoinhibitorinducerDetails
DB06016Cariprazineapproved, investigationalnoinhibitorDetails
DB06083Tapinarofapproved, investigationalnosubstrateDetails
DB01656RoflumilastapprovednosubstrateDetails
DB16650Deucravacitinibapproved, investigationalunknownsubstrateDetails
DB11793Niraparibapproved, investigationalnoinducerDetails
DB16267Olutasidenibapproved, investigationalnosubstrateinducerDetails
DB15568Adagrasibapproved, investigationalunknownsubstrateDetails
DB17472Pirtobrutinibapproved, investigationalunknowninhibitorDetails
DB00349Clobazamapproved, illicitnosubstrateDetails
DB16217Leniolisibapproved, investigationalnosubstrateinhibitorDetails
DB11712Tezacaftorapproved, investigationalnoinhibitorDetails
DB15669Fezolinetantapproved, investigationalnosubstrateDetails
DB14924Ritlecitinibapproved, investigationalunknownsubstrateinhibitorDetails
DB11763Momelotinibapproved, investigationalunknownsubstrateDetails
DB11718Encorafenibapproved, investigationalnoinhibitorDetails