Cytochrome P450 2A6
Details
- Name
- Cytochrome P450 2A6
- Synonyms
- 1,4-cineole 2-exo-monooxygenase
- 1.14.13.-
- Coumarin 7-hydroxylase
- CYP2A3
- CYPIIA6
- Cytochrome P450 IIA3
- Cytochrome P450(I)
- Gene Name
- CYP2A6
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037226|Cytochrome P450 2A6 MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK ISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSN GERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSN VISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQL LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFI GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQ RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLNEK GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGF ATIPRNYTMSFLPR
- Number of residues
- 494
- Molecular Weight
- 56501.005
- Theoretical pI
- 9.69
- GO Classification
- Functionsarachidonic acid epoxygenase activity / coumarin 7-hydroxylase activity / enzyme binding / heme binding / iron ion binding / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / oxygen binding / steroid hydroxylase activityProcessescoumarin catabolic process / coumarin metabolic process / drug metabolic process / epoxygenase P450 pathway / exogenous drug catabolic process / oxidation-reduction process / small molecule metabolic process / steroid metabolic process / xenobiotic metabolic processComponentscytoplasm / cytoplasmic microtubule / endoplasmic reticulum membrane / intracellular membrane-bounded organelle
- General Function
- Steroid hydroxylase activity
- Specific Function
- Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
- Pfam Domain Function
- p450 (PF00067)
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0021356|Cytochrome P450 2A6 (CYP2A6) ATGCTGGCCTCAGGGATGCTTCTGGTGGCCTTGCTGGTCTGCCTGACTGTAATGGTCTTG ATGTCTGTTTGGCAGCAGAGGAAGAGCAAGGGGAAGCTGCCTCCGGGACCCACCCCATTG CCCTTCATTGGAAACTACCTGCAGCTGAACACAGAGCAGATGTACAACTCCCTCATGAAG ATCAGTGAGCGCTATGGCCCCGTGTTCACCATTCACTTGGGGCCCCGGCGGGTCGTGGTG CTGTGTGGACATGATGCCGTCAGGGAGGCTCTGGTGGACCAGGCTGAGGAGTTCAGCGGG CGAGGCGAGCAAGCCACCTTCGACTGGGTCTTCAAAGGCTATGGCGTGGTATTCAGCAAC GGGGAGCGCGCCAAGCAGCTCCGGCGCTTCTCCATCGCCACCCTGCGGGACTTCGGGGTG GGCAAGCGAGGCATCGAGGAGCGCATCCAGGAGGAGGCGGGCTTCCTCATCGACGCCCTC CGGGGCACTGGCGGCGCCAATATCGATCCCACCTTCTTCCTGAGCCGCACAGTCTCCAAT GTCATCAGCTCCATTGTCTTTGGGGACCGCTTTGACTATAAGGACAAAGAGTTCCTGTCA CTGTTGCGCATGATGCTAGGAATCTTCCAGTTCACGTCAACCTCCACGGGGCAGCTCTAT GAGATGTTCTCTTCGGTGATGAAACACCTGCCAGGACCACAGCAACAGGCCTTTCAGTTG CTGCAAGGGCTGGAGGACTTCATAGCCAAGAAGGTGGAGCACAACCAGCGCACGCTGGAT CCCAATTCCCCACGGGACTTCATTGACTCCTTTCTCATCCGCATGCAGGAGGAGGAGAAG AACCCCAACACGGAGTTCTACTTGAAAAACCTGGTGATGACCACGTTGAACCTCTTCATT GGGGGCACCGAGACCGTCAGCACCACCCTGCGCTATGGCTTCTTGCTGCTCATGAAGCAC CCAGAGGTGGAGGCCAAGGTCCATGAGGAGATTGACAGAGTGATCGGCAAGAACCGGCAG CCCAAGTTTGAGGACCGGGCCAAGATGCCCTACATGGAGGCAGTGATCCACGAGATCCAA AGATTTGGAGACGTGATCCCCATGAGTTTGGCCCGCAGAGTCAAAAAGGACACCAAGTTT CGGGATTTCTTCCTCCCTAAGGGCACCGAAGTGTACCCTATGCTGGGCTCTGTGCTGAGA GACCCCAGTTTCTTCTCCAACCCCCAGGACTTCAATCCCCAGCACTTCCTGAATGAGAAG GGGCAGTTTAAGAAGAGTGATGCTTTTGTGCCCTTTTCCATCGGAAAGCGGAACTGTTTC GGAGAAGGCCTGGCCAGAATGGAGCTCTTTCTCTTCTTCACCACCGTCATGCAGAACTTC CGCCTCAAGTCCTCCCAGTCACCTAAGGACATTGACGTGTCCCCCAAACACGTGGGCTTT GCCACGATCCCACGAAACTACACCATGAGCTTCCTGCCCCGCTGA
- Chromosome Location
- 19
- Locus
- 19q13.2
- External Identifiers
Resource Link UniProtKB ID P11509 UniProtKB Entry Name CP2A6_HUMAN GenBank Gene ID X13897 GenAtlas ID CYP2A6 HGNC ID HGNC:2610 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB04665 Coumarin experimental unknown Details DB00184 Nicotine approved unknown substrateinhibitor Details DB01006 Letrozole approved, investigational unknown substrateinhibitor Details DB00356 Chlorzoxazone approved unknown substrate Details DB00553 Methoxsalen approved unknown inhibitor Details DB00752 Tranylcypromine approved, investigational unknown inhibitor Details DB01011 Metyrapone approved, investigational unknown inhibitor Details DB01085 Pilocarpine approved, investigational unknown substrateinhibitor Details DB01159 Halothane approved, vet_approved unknown substrate Details DB04977 Plitidepsin investigational unknown substrate Details DB01115 Nifedipine approved unknown substrate Details DB01037 Selegiline approved, investigational, vet_approved unknown substrateinhibitor Details DB01181 Ifosfamide approved unknown substrate Details DB00313 Valproic acid approved, investigational unknown substrate Details DB00238 Nevirapine approved unknown substrate Details DB00568 Cinnarizine approved, investigational unknown substrate Details DB04841 Flunarizine approved unknown substrate Details DB00471 Montelukast approved unknown substrate Details DB07609 N,N-DIMETHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE experimental unknown Details DB07617 N-METHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE experimental unknown Details DB07621 (5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE experimental unknown Details DB07623 4,4'-DIPYRIDYL DISULFIDE experimental unknown Details DB00182 Amphetamine approved, illicit, investigational unknown inhibitor Details DB00972 Azelastine approved unknown substrateinhibitor Details DB00604 Cisapride approved, investigational, withdrawn unknown substrate Details DB06470 Clomethiazole investigational unknown substrate Details DB00257 Clotrimazole approved, vet_approved unknown inhibitor Details DB00363 Clozapine approved no substrate Details DB00531 Cyclophosphamide approved, investigational unknown substrate Details DB01234 Dexamethasone approved, investigational, vet_approved unknown inducer Details DB00216 Eletriptan approved, investigational unknown inducer Details DB01544 Flunitrazepam approved, illicit unknown substrate Details DB00544 Fluorouracil approved unknown substrate Details DB01213 Fomepizole approved, vet_approved unknown inhibitor Details DB00951 Isoniazid approved, investigational unknown inhibitor Details DB01026 Ketoconazole approved, investigational unknown inhibitor Details DB00281 Lidocaine approved, vet_approved unknown substrate Details DB01043 Memantine approved, investigational unknown inhibitor Details DB00170 Menadione approved, nutraceutical unknown inhibitor Details DB01028 Methoxyflurane approved, investigational, vet_approved, withdrawn unknown substrate Details DB01110 Miconazole approved, investigational, vet_approved unknown inhibitor Details DB06712 Nilvadipine approved, investigational unknown inhibitor Details DB00316 Acetaminophen approved unknown substrate Details DB03783 Phenacetin withdrawn unknown substrate Details DB01435 Antipyrine approved, investigational unknown substrate Details DB01174 Phenobarbital approved, investigational unknown inducer Details DB00396 Progesterone approved, vet_approved unknown inducer Details DB01045 Rifampicin approved unknown inducer Details DB06739 Seratrodast experimental unknown inhibitor Details DB01236 Sevoflurane approved, vet_approved unknown substrate Details DB00675 Tamoxifen approved unknown substrate Details DB00763 Methimazole approved unknown inhibitor Details DB00495 Zidovudine approved unknown substrate Details DB00690 Flurazepam approved, illicit, investigational unknown substrate Details DB00755 Tretinoin approved, investigational, nutraceutical unknown substrate Details DB01274 Arformoterol approved, investigational unknown substrate Details DB04871 Lorcaserin approved, withdrawn no substrate Details DB01118 Amiodarone approved, investigational unknown inhibitor Details DB00312 Pentobarbital approved, investigational, vet_approved unknown inducer Details DB06292 Dapagliflozin approved no substrate Details DB09068 Vortioxetine approved, investigational no substrate Details DB09256 Tegafur approved, investigational no substrate Details DB09327 Tegafur-uracil approved, investigational no substrate Details DB11586 Asunaprevir approved, investigational, withdrawn no substrate Details DB09274 Artesunate approved, investigational unknown substrate Details DB12245 Triclabendazole approved, investigational unknown inhibitor Details DB00916 Metronidazole approved unknown substrate Details DB05676 Apremilast approved, investigational unknown substrate Details DB01039 Fenofibrate approved unknown inhibitor Details DB00717 Norethisterone approved unknown substrate Details DB00635 Prednisone approved, vet_approved unknown inducer Details DB00741 Hydrocortisone approved, vet_approved unknown inducer Details DB06119 Cenobamate approved, investigational unknown substrate Details DB01222 Budesonide approved unknown inducer Details DB00959 Methylprednisolone approved, vet_approved unknown inducer Details DB00252 Phenytoin approved, vet_approved no substrate Details DB00983 Formoterol approved, investigational unknown substrate Details DB00443 Betamethasone approved, vet_approved unknown inducer Details DB14631 Prednisolone phosphate approved, vet_approved unknown inducer Details DB14649 Dexamethasone acetate approved, investigational, vet_approved unknown inducer Details DB06448 Lonafarnib approved, investigational no substrate Details DB00330 Ethambutol approved unknown inhibitor Details DB15119 Ropeginterferon alfa-2b approved, investigational no inhibitor Details DB09061 Cannabidiol approved, investigational unknown inhibitor Details DB00470 Dronabinol approved, illicit no inhibitor Details DB14737 Cannabinol experimental, investigational unknown inhibitor Details DB14009 Medical Cannabis experimental, investigational unknown inhibitor Details DB12816 Terpinen-4-ol investigational no substrate Details DB06374 Elacestrant approved, investigational unknown substrate Details DB01194 Brinzolamide approved no substrate Details