Aspartate aminotransferase, cytoplasmic
Details
- Name
- Aspartate aminotransferase, cytoplasmic
- Synonyms
- 2.6.1.1
- cAspAT
- cCAT
- Cysteine aminotransferase, cytoplasmic
- Cysteine transaminase, cytoplasmic
- Glutamate oxaloacetate transaminase 1
- Transaminase A
- Gene Name
- GOT1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037039|Aspartate aminotransferase, cytoplasmic MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQK IANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFL ARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLEN APEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWA IRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPP AQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGM FSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ
- Number of residues
- 413
- Molecular Weight
- 46247.14
- Theoretical pI
- 7.01
- GO Classification
- Functionscarboxylic acid binding / identical protein binding / L-aspartate / L-cysteine / L-phenylalanine / phosphatidylserine decarboxylase activity / pyridoxal phosphate bindingProcesses2-oxoglutarate metabolic process / aspartate biosynthetic process / aspartate catabolic process / aspartate metabolic process / carbohydrate metabolic process / cellular amino acid biosynthetic process / cellular nitrogen compound metabolic process / cellular response to insulin stimulus / fatty acid homeostasis / gluconeogenesis / glucose metabolic process / glutamate catabolic process to 2-oxoglutarate / glutamate catabolic process to aspartate / glutamate metabolic process / glycerol biosynthetic process / L-methionine biosynthetic process from methylthioadenosine / Notch signaling pathway / oxaloacetate metabolic process / polyamine metabolic process / response to glucocorticoid / small molecule metabolic process / sulfur amino acid metabolic processComponentsaxon terminus / cytoplasm / cytosol / extracellular exosome / lysosome / nucleus
- General Function
- Pyridoxal phosphate binding
- Specific Function
- Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
- Pfam Domain Function
- Aminotran_1_2 (PF00155)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0010371|Aspartate aminotransferase, cytoplasmic (GOT1) ATGGCACCTCCGTCAGTCTTTGCCGAGGTTCCGCAGGCCCAGCCTGTCCTGGTCTTCAAG CTCACTGCCGACTTCAGGGAGGATCCGGACCCCCGCAAGGTCAACCTGGGAGTGGGAGCA TATCGCACGGATGACTGCCATCCCTGGGTTTTGCCAGTAGTGAAGAAAGTGGAGCAGAAG ATTGCTAATGACAATAGCCTAAATCACGAGTATCTGCCAATCCTGGGCCTGGCTGAGTTC CGGAGCTGTGCTTCTCGTCTTGCCCTTGGGGATGACAGCCCAGCACTCAAGGAGAAGCGG GTAGGAGGTGTGCAATCTTTGGGGGGAACAGGTGCACTTCGAATTGGAGCTGATTTCTTA GCGCGTTGGTACAATGGAACAAACAACAAGAACACACCTGTCTATGTGTCCTCACCAACC TGGGAGAATCACAATGCTGTGTTTTCCGCTGCTGGTTTTAAAGACATTCGGTCCTATCGC TACTGGGATGCAGAGAAGAGAGGATTGGACCTCCAGGGCTTCCTGAATGATCTGGAGAAT GCTCCTGAGTTCTCCATTGTTGTCCTCCACGCCTGTGCACACAACCCAACTGGGATTGAC CCAACTCCGGAGCAGTGGAAGCAGATTGCTTCTGTCATGAAGCACCGGTTTCTGTTCCCC TTCTTTGACTCAGCCTATCAGGGCTTCGCATCTGGAAACCTGGAGAGAGATGCCTGGGCC ATTCGCTATTTTGTGTCTGAAGGCTTCGAGTTCTTCTGTGCCCAGTCCTTCTCCAAGAAC TTCGGGCTCTACAATGAGAGAGTCGGGAATCTGACTGTGGTTGGAAAAGAACCTGAGAGC ATCCTGCAAGTCCTTTCCCAGATGGAGAAGATCGTGCGGATTACTTGGTCCAATCCCCCC GCCCAGGGAGCACGAATTGTGGCCAGCACCCTCTCTAACCCTGAGCTCTTTGAGGAATGG ACAGGTAATGTGAAGACAATGGCTGACCGGATTCTGACCATGAGATCTGAACTCAGGGCA CGACTAGAAGCCCTCAAAACCCCTGGGACCTGGAACCACATCACTGATCAAATTGGCATG TTCAGCTTCACTGGGTTGAACCCCAAGCAGGTTGAGTATCTGGTCAATGAAAAGCACATC TACCTGCTGCCAAGTGGTCGAATCAACGTGAGTGGCTTAACCACCAAAAATCTAGATTAC GTGGCCACCTCCATCCATGAAGCAGTCACCAAAATCCAGTGA
- Chromosome Location
- 10
- Locus
- 10q24.1-q25.1
- External Identifiers
Resource Link UniProtKB ID P17174 UniProtKB Entry Name AATC_HUMAN GenBank Protein ID 179067 GenBank Gene ID M37400 GenAtlas ID GOT1 HGNC ID HGNC:4432 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00114 Pyridoxal phosphate approved, investigational, nutraceutical unknown activator Details DB00128 Aspartic acid approved, nutraceutical unknown Details DB00151 Cysteine approved, nutraceutical unknown substrate Details DB00142 Glutamic acid approved, nutraceutical unknown Details DB04299 Maleic acid experimental unknown Details DB09130 Copper approved, investigational unknown Details DB00210 Adapalene approved unknown inhibitor Details DB00114 Pyridoxal phosphate approved, investigational, nutraceutical unknown cofactor Details DB00142 Glutamic acid approved, nutraceutical unknown substrate Details