Alpha-1-acid glycoprotein 2

Details

Name
Alpha-1-acid glycoprotein 2
Synonyms
  • AGP 2
  • AGP2
  • OMD 2
  • Orosomucoid-2
Gene Name
ORM2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0007040|Alpha-1-acid glycoprotein 2
MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQ
EIQATFFYFTPNKTEDTIFLREYQTRQNQCFYNSSYLNVQRENGTVSRYEGGREHVAHLL
FLRDTKTLMFGSYLDDEKNWGLSFYADKPETTKEQLGEFYEALDCLCIPRSDVMYTDWKK
DKCEPLEKQHEKERKQEEGES
Number of residues
201
Molecular Weight
23602.43
Theoretical pI
4.76
GO Classification
Processes
acute-phase response / regulation of immune system process / transport
Components
blood microparticle / extracellular exosome / extracellular space
General Function
Not Available
Specific Function
Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0012546|Alpha-1-acid glycoprotein 2 (ORM2)
ATGGCGCTGTCCTGGGTTCTTACAGTCCTGAGCCTCCTACCTCTGCTGGAAGCCCAGATC
CCATTGTGTGCCAACCTAGTACCGGTGCCCATCACCAACGCCACCCTGGACCGGATCACT
GGCAAGTGGTTTTATATCGCATCGGCCTTTCGAAACGAGGAGTACAATAAGTCGGTTCAG
GAGATCCAAGCAACCTTCTTTTACTTTACCCCCAACAAGACAGAGGACACGATCTTTCTC
AGAGAGTACCAGACCCGCCAGAACCAGTGCTTCTATAACTCCAGTTACCTGAATGTCCAG
CGGGAGAATGGGACCGTCTCCAGATACGAGGGAGGCCGAGAACATGTTGCTCACCTGCTG
TTCCTTAGGGACACCAAGACCTTGATGTTTGGTTCCTACCTGGACGATGAGAAGAACTGG
GGGCTGTCTTTCTATGCTGACAAGCCAGAGACGACCAAGGAGCAACTGGGAGAGTTCTAC
GAAGCTCTCGACTGCTTGTGCATTCCCAGGTCAGATGTCATGTACACCGACTGGAAAAAG
GATAAGTGTGAGCCACTGGAGAAGCAGCACGAGAAGGAGAGGAAACAGGAGGAGGGGGAA
TCCTAG
Chromosome Location
9
Locus
9q32
External Identifiers
ResourceLink
UniProtKB IDP19652
UniProtKB Entry NameA1AG2_HUMAN
GenBank Protein ID16359000
GenBank Gene IDBC015964
HGNC IDHGNC:8499
General References
  1. Dente L, Pizza MG, Metspalu A, Cortese R: Structure and expression of the genes coding for human alpha 1-acid glycoprotein. EMBO J. 1987 Aug;6(8):2289-96. [Article]
  2. Merritt CM, Board PG: Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene. Gene. 1988 Jun 15;66(1):97-106. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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  5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  6. Schmid K, Burgi W, Collins JH, Nanno S: The disulfide bonds of alpha1-acid glycoprotein. Biochemistry. 1974 Jun 18;13(13):2694-7. [Article]
  7. Treuheit MJ, Costello CE, Halsall HB: Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein. Biochem J. 1992 Apr 1;283 ( Pt 1):105-12. [Article]
  8. Hagglund P, Bunkenborg J, Elortza F, Jensen ON, Roepstorff P: A new strategy for identification of N-glycosylated proteins and unambiguous assignment of their glycosylation sites using HILIC enrichment and partial deglycosylation. J Proteome Res. 2004 May-Jun;3(3):556-66. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01593Zincapproved, investigationalunknownDetails
DB00280DisopyramideapprovedunknownDetails
DB00458ImipramineapprovedunknownDetails
DB00281Lidocaineapproved, vet_approvedunknownDetails
DB14487Zinc acetateapproved, investigationalunknownDetails
DB14533Zinc chlorideapproved, investigationalunknownbinderDetails
DB14548Zinc sulfate, unspecified formapproved, experimentalunknownbinderDetails
DB00477Chlorpromazineapproved, investigational, vet_approvedunknownbinderDetails
DB01041Thalidomideapproved, investigational, withdrawnyesbinderDetails
DB09262ImidafenacininvestigationalnosubstrateDetails
DB11828Neratinibapproved, investigationalnosubstrateDetails
DB00512VancomycinapprovednosubstrateDetails
DB12001Abemaciclibapproved, investigationalunknownbinderDetails
DB09053IbrutinibapprovednosubstrateDetails
DB11641Vinflunineapproved, investigationalnosubstrateDetails
DB14582Patisiranapproved, investigationalunknownligandDetails
DB00289AtomoxetineapprovednobinderDetails
DB00332Ipratropiumapproved, experimentalnobinderDetails
DB00404Alprazolamapproved, illicit, investigationalunknownbinderDetails
DB00421SpironolactoneapprovedunknownbinderDetails
DB00476DuloxetineapprovedunknownligandDetails
DB00497Oxycodoneapproved, illicit, investigationalunknownbinderDetails
DB00813Fentanylapproved, illicit, investigational, vet_approvedunknownbinderDetails
DB01029Irbesartanapproved, investigationalunknownbinderDetails
DB01591SolifenacinapprovedunknownbinderDetails
DB00598LabetalolapprovedunknownsubstrateDetails
DB01203NadololapprovedunknownbinderDetails
DB01611HydroxychloroquineapprovedunknownbinderDetails
DB01045RifampicinapprovedunknownligandDetails
DB11757Istradefyllineapproved, investigationalunknownbinderDetails
DB01195Flecainideapproved, withdrawnunknownbinderDetails
DB00278Argatrobanapproved, investigationalunknownbinderDetails
DB06216AsenapineapprovedunknownbinderDetails
DB01072Atazanavirapproved, investigationalnobinderDetails
DB11703Acalabrutinibapproved, investigationalunknownbinderDetails
DB00857Terbinafineapproved, investigational, vet_approvedunknownbinderDetails
DB00950Fexofenadineapproved, investigationalunknownsubstrateDetails
DB01115NifedipineapprovedunknownbinderDetails
DB00938SalmeterolapprovedunknownbinderDetails
DB00608Chloroquineapproved, investigational, vet_approvedunknownbinderDetails
DB12466Favipiravirapproved, investigationalunknowncarrierDetails
DB00907Cocaineapproved, illicitunknownbinderDetails
DB11689Selumetinibapproved, investigationalunknowncarrierDetails
DB14840RipretinibapprovedunknownbinderDetails
DB00808IndapamideapprovedunknownbinderDetails
DB00409Remoxiprideapproved, withdrawnunknownbinderDetails
DB00960Pindololapproved, investigationalunknownbinderDetails
DB01086Benzocaineapproved, investigationalunknownbinderDetails
DB00986Glycopyrroniumapproved, investigational, vet_approvedunknownbinderDetails
DB08932MacitentanapprovednobinderDetails
DB00342Terfenadineapproved, withdrawnunknownbinderregulatorDetails
DB00748CarbinoxamineapprovedunknownbinderregulatorDetails
DB08865Crizotinibapproved, investigationalunknownbinderDetails
DB08930DolutegravirapprovednobinderDetails
DB12147Erdafitinibapproved, investigationalnobinderDetails
DB11978Glasdegibapproved, investigationalnobinderDetails
DB12005Nirogacestatapproved, investigationalnobinderDetails