Mitogen-activated protein kinase 3

Details

Name
Mitogen-activated protein kinase 3
Synonyms
  • 2.7.11.24
  • ERK-1
  • ERK1
  • ERT2
  • Extracellular signal-regulated kinase 1
  • Insulin-stimulated MAP2 kinase
  • MAP kinase 3
  • MAP kinase isoform p44
  • Microtubule-associated protein 2 kinase
  • p44-ERK1
  • p44-MAPK
  • PRKM3
Gene Name
MAPK3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0002115|Mitogen-activated protein kinase 3
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP
Number of residues
379
Molecular Weight
43135.16
Theoretical pI
6.74
GO Classification
Functions
ATP binding / MAP kinase activity / phosphatase binding
Processes
activation of MAPK activity / activation of MAPKK activity / apoptotic process / arachidonic acid metabolic process / axon guidance / blood coagulation / BMP signaling pathway / cartilage development / caveolin-mediated endocytosis / cell cycle / cellular response to heat / cellular response to mechanical stimulus / cytokine-mediated signaling pathway / DNA damage induced protein phosphorylation / epidermal growth factor receptor signaling pathway / ERK1 and ERK2 cascade / Fc-epsilon receptor signaling pathway / Fc-gamma receptor signaling pathway involved in phagocytosis / fibroblast growth factor receptor signaling pathway / gene expression / innate immune response / insulin receptor signaling pathway / interleukin-1-mediated signaling pathway / JAK-STAT cascade involved in growth hormone signaling pathway / lipopolysaccharide-mediated signaling pathway / lung morphogenesis / MAPK cascade / MAPK import into nucleus / MyD88-dependent toll-like receptor signaling pathway / MyD88-independent toll-like receptor signaling pathway / negative regulation of apolipoprotein binding / neurotrophin TRK receptor signaling pathway / peptidyl-serine phosphorylation / peptidyl-tyrosine autophosphorylation / phosphorylation / platelet activation / positive regulation of cyclase activity / positive regulation of ERK1 and ERK2 cascade / positive regulation of histone acetylation / positive regulation of histone phosphorylation / positive regulation of protein phosphorylation / positive regulation of telomerase activity / positive regulation of telomere capping / positive regulation of telomere maintenance via telomerase / positive regulation of transcription from RNA polymerase II promoter / positive regulation of translation / protein complex assembly / protein phosphorylation / Ras protein signal transduction / regulation of cellular response to heat / regulation of cytoskeleton organization / regulation of early endosome to late endosome transport / regulation of Golgi inheritance / regulation of sequence-specific DNA binding transcription factor activity / regulation of stress-activated MAPK cascade / response to epidermal growth factor / response to exogenous dsRNA / response to toxic substance / sensory perception of pain / small GTPase mediated signal transduction / stress-activated MAPK cascade / toll-like receptor 10 signaling pathway / toll-like receptor 2 signaling pathway / toll-like receptor 3 signaling pathway / toll-like receptor 4 signaling pathway / toll-like receptor 5 signaling pathway / toll-like receptor 9 signaling pathway / toll-like receptor signaling pathway / toll-like receptor TLR1 / toll-like receptor TLR6 / trachea formation / transcription from RNA polymerase I promoter / transcription initiation from RNA polymerase I promoter / TRIF-dependent toll-like receptor signaling pathway / vascular endothelial growth factor receptor signaling pathway / viral process
Components
caveola / cytoskeleton / cytosol / early endosome / extracellular exosome / focal adhesion / Golgi apparatus / late endosome / microtubule cytoskeleton / mitochondrion / nuclear envelope / nucleoplasm / nucleus / protein complex / pseudopodium
General Function
Phosphatase binding
Specific Function
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0021655|Mitogen-activated protein kinase 3 (MAPK3)
ATGGCGGCGGCGGCGGCTCAGGGGGGCGGGGGCGGGGAGCCCCGTAGAACCGAGGGGGTC
GGCCCGGGGGTCCCGGGGGAGGTGGAGATGGTGAAGGGGCAGCCGTTCGACGTGGGCCCG
CGCTACACGCAGTTGCAGTACATCGGCGAGGGCGCGTACGGCATGGTCAGCTCGGCCTAT
GACCACGTGCGCAAGACTCGCGTGGCCATCAAGAAGATCAGCCCCTTCGAACATCAGACC
TACTGCCAGCGCACGCTCCGGGAGATCCAGATCCTGCTGCGCTTCCGCCATGAGAATGTC
ATCGGCATCCGAGACATTCTGCGGGCGTCCACCCTGGAAGCCATGAGAGATGTCTACATT
GTGCAGGACCTGATGGAGACTGACCTGTACAAGTTGCTGAAAAGCCAGCAGCTGAGCAAT
GACCATATCTGCTACTTCCTCTACCAGATCCTGCGGGGCCTCAAGTACATCCACTCCGCC
AACGTGCTCCACCGAGATCTAAAGCCCTCCAACCTGCTCATCAACACCACCTGCGACCTT
AAGATTTGTGATTTCGGCCTGGCCCGGATTGCCGATCCTGAGCATGACCACACCGGCTTC
CTGACGGAGTATGTGGCTACGCGCTGGTACCGGGCCCCAGAGATCATGCTGAACTCCAAG
GGCTATACCAAGTCCATCGACATCTGGTCTGTGGGCTGCATTCTGGCTGAGATGCTCTCT
AACCGGCCCATCTTCCCTGGCAAGCACTACCTGGATCAGCTCAACCACATTCTGGGCATC
CTGGGCTCCCCATCCCAGGAGGACCTGAATTGTATCATCAACATGAAGGCCCGAAACTAC
CTACAGTCTCTGCCCTCCAAGACCAAGGTGGCTTGGGCCAAGCTTTTCCCCAAGTCAGAC
TCCAAAGCCCTTGACCTGCTGGACCGGATGTTAACCTTTAACCCCAATAAACGGATCACA
GTGGAGGAAGCGCTGGCTCACCCCTACCTGGAGCAGTACTATGACCCGACGGATGAGGTG
GGCCAGTCCCCAGCAGCAGTGGGGCTGGGGGCAGGGGAGCAGGGGGGCACGTAG
Chromosome Location
16
Locus
16p11.2
External Identifiers
ResourceLink
UniProtKB IDP27361
UniProtKB Entry NameMK03_HUMAN
GenBank Protein ID31221
GenBank Gene IDX60188
GenAtlas IDMAPK3
HGNC IDHGNC:6877
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00605Sulindacapproved, investigationalunknowninhibitorDetails
DB01169Arsenic trioxideapproved, investigationalyesinducerDetails
DB02733PurvalanolexperimentalunknowninhibitorDetails
DB06195SeliciclibinvestigationalunknownDetails
DB046045-iodotubercidinexperimentalunknownDetails
DB13930UlixertinibinvestigationalunknowninhibitorDetails
DB08862Cholecystokininapproved, investigationalunknownDetails
DB00945Acetylsalicylic acidapproved, vet_approvedunknownDetails
DB02587Colforsinexperimental, investigationalunknownactivatorDetails
DB01017Minocyclineapproved, investigationalunknowninhibitorDetails