Glutamine synthetase
Details
- Name
- Glutamine synthetase
- Synonyms
- 6.3.1.2
- glnA
- Glutamate--ammonia ligase
- Glutamine synthetase I beta
- GS
- GSI beta
- Gene Name
- glnA1
- Organism
- Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
- Amino acid sequence
>lcl|BSEQ0051142|Glutamine synthetase MTEKTPDDVFKLAKDEKVEYVDVRFCDLPGIMQHFTIPASAFDKSVFDDGLAFDGSSIRG FQSIHESDMLLLPDPETARIDPFRAAKTLNINFFVHDPFTLEPYSRDPRNIARKAENYLI STGIADTAYFGAEAEFYIFDSVSFDSRANGSFYEVDAISGWWNTGAATEADGSPNRGYKV RHKGGYFPVAPNDQYVDLRDKMLTNLINSGFILEKGHHEVGSGGQAEINYQFNSLLHAAD DMQLYKYIIKNTAWQNGKTVTFMPKPLFGDNGSGMHCHQSLWKDGAPLMYDETGYAGLSD TARHYIGGLLHHAPSLLAFTNPTVNSYKRLVPGYEAPINLVYSQRNRSACVRIPITGSNP KAKRLEFRSPDSSGNPYLAFSAMLMAGLDGIKNKIEPQAPVDKDLYELPPEEAASIPQTP TQLSDVIDRLEADHEYLTEGGVFTNDLIETWISFKRENEIEPVNIRPHPYEFALYYDV
- Number of residues
- 478
- Molecular Weight
- 53569.475
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / glutamate-ammonia ligase activity / metal ion bindingProcessesglutamine biosynthetic process / nitrogen fixation / pathogenesisComponentscytoplasm
- General Function
- Involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Also plays a key role in controlling the ammonia levels within infected host cells and so contributes to the pathogens capacity to inhibit phagosome acidification and phagosome-lysosome fusion. Involved in cell wall biosynthesis via the production of the major component poly-L-glutamine (PLG). PLG synthesis in the cell wall occurs only in nitrogen limiting conditions and on the contrary high nitrogen conditions inhibit PLG synthesis.
- Specific Function
- Atp binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051143|Glutamine synthetase (glnA1) GTGACGGAAAAGACGCCCGACGACGTCTTCAAACTTGCCAAGGACGAGAAGGTCGAATAT GTCGACGTCCGGTTCTGTGACCTGCCTGGCATCATGCAGCACTTCACGATTCCGGCTTCG GCCTTTGACAAGAGCGTGTTTGACGACGGCTTGGCCTTTGACGGCTCGTCGATTCGCGGG TTCCAGTCGATCCACGAATCCGACATGTTGCTTCTTCCCGATCCCGAGACGGCGCGCATC GACCCGTTCCGCGCGGCCAAGACGCTGAATATCAACTTCTTTGTGCACGACCCGTTCACC CTGGAGCCGTACTCCCGCGACCCGCGCAACATCGCCCGCAAGGCCGAGAACTACCTGATC AGCACTGGCATCGCCGACACCGCATACTTCGGCGCCGAGGCCGAGTTCTACATTTTCGAT TCGGTGAGCTTCGACTCGCGCGCCAACGGCTCCTTCTACGAGGTGGACGCCATCTCGGGG TGGTGGAACACCGGCGCGGCGACCGAGGCCGACGGCAGTCCCAACCGGGGCTACAAGGTC CGCCACAAGGGCGGGTATTTCCCAGTGGCCCCCAACGACCAATACGTCGACCTGCGCGAC AAGATGCTGACCAACCTGATCAACTCCGGCTTCATCCTGGAGAAGGGCCACCACGAGGTG GGCAGCGGCGGACAGGCCGAGATCAACTACCAGTTCAATTCGCTGCTGCACGCCGCCGAC GACATGCAGTTGTACAAGTACATCATCAAGAACACCGCCTGGCAGAACGGCAAAACGGTC ACGTTCATGCCCAAGCCGCTGTTCGGCGACAACGGGTCCGGCATGCACTGTCATCAGTCG CTGTGGAAGGACGGGGCCCCGCTGATGTACGACGAGACGGGTTATGCCGGTCTGTCGGAC ACGGCCCGTCATTACATCGGCGGCCTGTTACACCACGCGCCGTCGCTGCTGGCCTTCACC AACCCGACGGTGAACTCCTACAAGCGGCTGGTTCCCGGTTACGAGGCCCCGATCAACCTG GTCTATAGCCAGCGCAACCGGTCGGCATGCGTGCGCATCCCGATCACCGGCAGCAACCCG AAGGCCAAGCGGCTGGAGTTCCGAAGCCCCGACTCGTCGGGCAACCCGTATCTGGCGTTC TCGGCCATGCTGATGGCAGGCCTGGACGGTATCAAGAACAAGATCGAGCCGCAGGCGCCC GTCGACAAGGATCTCTACGAGCTGCCGCCGGAAGAGGCCGCGAGTATCCCGCAGACTCCG ACCCAGCTGTCAGATGTGATCGACCGTCTCGAGGCCGACCACGAATACCTCACCGAAGGA GGGGTGTTCACAAACGACCTGATCGAGACGTGGATCAGTTTCAAGCGCGAAAACGAGATC GAGCCGGTCAACATCCGGCCGCATCCCTACGAATTCGCGCTGTACTACGACGTTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WN38 UniProtKB Entry Name GLN1B_MYCTO - General References
- Fleischmann RD, Alland D, Eisen JA, Carpenter L, White O, Peterson J, DeBoy R, Dodson R, Gwinn M, Haft D, Hickey E, Kolonay JF, Nelson WC, Umayam LA, Ermolaeva M, Salzberg SL, Delcher A, Utterback T, Weidman J, Khouri H, Gill J, Mikula A, Bishai W, Jacobs Jr WR Jr, Venter JC, Fraser CM: Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains. J Bacteriol. 2002 Oct;184(19):5479-90. [Article]