Reaction: (R)-Fluoxetine to 1 product
- Reaction
- Reaction type
- N-dealkylation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Brown CM, Reisfeld B, Mayeno AN: Cytochromes P450: a structure-based summary of biotransformations using representative substrates. Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742 . [Article]
- Ring BJ, Eckstein JA, Gillespie JS, Binkley SN, VandenBranden M, Wrighton SA: Identification of the human cytochromes p450 responsible for in vitro formation of R- and S-norfluoxetine. J Pharmacol Exp Ther. 2001 Jun;297(3):1044-50. [Article]
- Margolis JM, O'Donnell JP, Mankowski DC, Ekins S, Obach RS: (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes. Drug Metab Dispos. 2000 Oct;28(10):1187-91. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 2C9 Not Available Not Available implied Cytochrome P450 2D6 Not Available Not Available implied Cytochrome P450 2C19 Not Available Not Available implied Cytochrome P450 3A5 Not Available Not Available implied
