Identification
- Brand Names
- Irospan 24/6 Kit
- Generic Name
- Formic acid
- DrugBank Accession Number
- DB01942
- Background
Formic acid (systematically called methanoic acid) is the simplest carboxylic acid. It is an important intermediate in chemical synthesis and occurs naturally, most famously in the venom of bee and ant stings. It is commonly used as a preservative and antibacterial agent in livestock feed.
- Type
- Small Molecule
- Groups
- Experimental, Investigational
- Structure
Structure for Formic acid (DB01942)
- Weight
- Average: 46.0254
Monoisotopic: 46.005479308 - Chemical Formula
- CH2O2
- Synonyms
- Acide formique
- Ameisensäure
- Aminic acid
- Bilorin
- Formic acid
- Formylic acid
- Hydrogen carboxylic acid
- Methanoic acid
- External IDs
- E236
- FEMA NO. 2487
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UPutative hydroxypyruvate isomerase YgbM Not Available Escherichia coli (strain K12) UDelta-aminolevulinic acid dehydratase Not Available Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) UHeme oxygenase 1 Not Available Humans URibonuclease pancreatic Not Available Humans U3-phosphoshikimate 1-carboxyvinyltransferase Not Available Escherichia coli (strain K12) USubtilisin Carlsberg Not Available Bacillus licheniformis UFibroblast growth factor 1 Not Available Humans UPeptide deformylase Not Available Escherichia coli (strain K12) UPara-aminobenzoate synthase component 1 Not Available Escherichia coli (strain K12) UCarbonic anhydrase 2 Not Available Humans UDihydroorotate dehydrogenase (quinone) Not Available Escherichia coli (strain K12) U(S)-2-haloacid dehalogenase Not Available Xanthobacter autotrophicus UBeta-lactamase OXA-2 Not Available Salmonella typhimurium UCatalase Not Available Proteus mirabilis USignal recognition particle protein Not Available Thermus aquaticus UStreptavidin Not Available Streptomyces avidinii UMethylglyoxal synthase Not Available Shigella flexneri UC-terminal-binding protein 1 Not Available Humans U6-phosphogluconolactonase Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UCitrate lyase subunit beta-like protein Not Available Mycobacterium tuberculosis UPeripheral plasma membrane protein CASK Not Available Humans UGuanylate kinase Not Available Mycobacterium tuberculosis UProbable butyrate kinase 2 Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UGamma-glutamylaminecyclotransferase Not Available Humans UParvalbumin alpha Not Available Humans UAcylphosphatase-2 Not Available Humans UUncharacterized protein Not Available Bacillus cereus (strain ATCC 14579 / DSM 31) UArginine N-succinyltransferase subunit alpha Not Available Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) UPutative mannose-6-phosphate isomerase YvyI Not Available Bacillus subtilis (strain 168) UNitric oxide synthase, brain Not Available Humans UABC-type transporter, periplasmic subunit Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UProbable phosphatase YcdX Not Available Escherichia coli (strain K12) UPhenazine biosynthesis protein PhzD Not Available Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) UOxalate decarboxylase OxdC Not Available Bacillus subtilis (strain 168) UPutative ketoacyl reductase Not Available Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) UGephyrin Not Available Humans UGlyoxalase family protein Not Available Bacillus cereus (strain ATCC 14579 / DSM 31) UCytohesin-2 Not Available Humans UGlutaconyl-CoA decarboxylase subunit alpha Not Available Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4) UTranscriptional regulator, IclR family Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UCatalase Not Available Helicobacter pylori (strain ATCC 700392 / 26695) UPutative L-rhamnose mutarotase Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UGlutathione S-transferase Not Available Plasmodium falciparum UHypoxanthine-guanine phosphoribosyltransferase Not Available Trypanosoma cruzi UGlutaminase 1 Not Available Bacillus subtilis (strain 168) UGlutaminase 1 Not Available Escherichia coli (strain K12) UMolybdopterin synthase catalytic subunit Not Available Escherichia coli (strain K12) UAminotransferase, putative Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UIron binding protein FbpA Not Available Pasteurella haemolytica UDNA gyrase subunit B Not Available Thermus thermophilus - Absorption
Formic acid is readily metabolized and eliminated by the body.
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
ORAL (LD50): Acute: 700 mg/kg [Mouse]. 1100 mg/kg [Rat]. 4000 mg/kg [Dog].
- Pathways
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbciximab The therapeutic efficacy of Formic acid can be decreased when used in combination with Abciximab. Acenocoumarol The therapeutic efficacy of Formic acid can be decreased when used in combination with Acenocoumarol. Alpha-1-proteinase inhibitor Alpha-1-proteinase inhibitor may increase the thrombogenic activities of Formic acid. Alteplase The therapeutic efficacy of Formic acid can be decreased when used in combination with Alteplase. Aminocaproic acid The risk or severity of adverse effects can be increased when Aminocaproic acid is combined with Formic acid. - Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Calcium formate NP3JD65NPY 544-17-2 CBOCVOKPQGJKKJ-UHFFFAOYSA-L - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Irospan 24/6 Calcium formate (155 mg/1) + Biotin (300 ug/1) + Biotin (300 ug/1) + Calcium carbonate (100 mg/1) + Cyanocobalamin (10 ug/1) + Cyanocobalamin (10 ug/1) + Ferrous bisglycinate (65 mg/1) + Folic acid (1 mg/1) + Folic acid (1 mg/1) + Iron Dextran (65 mg/1) + Niacin (25 mg/1) + Niacin (25 mg/1) + Calcium pantothenate (300 ug/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Riboflavin sodium (5 mg/1) + Riboflavin (5 mg/1) + Sodium ascorbate (100 mg/1) + Sodium ascorbate (100 mg/1) + Succinic acid (150 mg/1) + Thiamine hydrochloride (5 mg/1) + Thiamine hydrochloride (5 mg/1) Kit; Tablet; Tablet, film coated Oral WOMENS CHOICE PHARMACEUTICALS LLC 2011-04-15 Not applicable US 
NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Calcium formate (155 mg/1) + Calcium carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + Doconexent (230 mg/1) + Ferrous bisglycinate (32 mg/1) + Folic acid (1 mg/1) + Icosapent (30 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Tocopherylquinone (30 [iU]/1) + Vitamin E (2 [iU]/1) + Zinc oxide (10 mg/1) Capsule, gelatin coated; Kit; Tablet Oral WOMENS CHOICE PHARMACEUTICALS LLC 2011-02-01 Not applicable US NESTABS Prenatal Multi-vitamin/Mineral Supplement Calcium formate (155 mg/1) + Calcium carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + D-alpha-Tocopherol acetate (30 [iU]/1) + Ferrous bisglycinate (32 mg/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (10 mg/1) Tablet, film coated Oral WOMENS CHOICE PHARMACEUTICALS LLC 2011-02-01 Not applicable US Nutri-Tab OB Calcium formate (155 mg/1) + Calcium carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + D-alpha-Tocopherol acetate (30 [iU]/1) + Ferrous bisglycinate (32 mg/1) + Folic acid (1000 ug/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (10 mg/1) Tablet Oral Wh Nutritionals, Llc 2012-05-03 2014-10-31 US Nutri-Tab OB plus DHA Calcium formate (155 mg/1) + Calcium carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + D-alpha-Tocopherol acetate (30 [iU]/1) + Doconexent (230 mg/1) + Ferrous bisglycinate (32 mg/1) + Folic acid (1000 ug/1) + Icosapent (30 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (10 mg/1) Tablet Oral Wh Nutritionals, Llc 2012-05-03 2014-10-31 US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as carboxylic acids. These are compounds containing a carboxylic acid group with the formula -C(=O)OH.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Carboxylic acids
- Direct Parent
- Carboxylic acids
- Alternative Parents
- Monocarboxylic acids and derivatives / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Aliphatic acyclic compound / Carbonyl group / Carboxylic acid / Hydrocarbon derivative / Monocarboxylic acid or derivatives / Organic oxide / Organic oxygen compound / Organooxygen compound
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- monocarboxylic acid (CHEBI:30751) / Straight chain fatty acids, Saturated fatty acids (C00058)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 0YIW783RG1
- CAS number
- 64-18-6
- InChI Key
- BDAGIHXWWSANSR-UHFFFAOYSA-N
- InChI
- InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)
- IUPAC Name
- formic acid
- SMILES
- [H]C(O)=O
References
- Synthesis Reference
Gunter Roscher, Helmut Schaum, Heinz Schmitz, "Process for the preparation of practically formic acid-free acetic acid." U.S. Patent US4380663, issued August, 1944.
US4380663- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0000142
- KEGG Compound
- C00058
- PubChem Compound
- 284
- PubChem Substance
- 46508355
- ChemSpider
- 278
- 4537
- ChEBI
- 30751
- ChEMBL
- CHEMBL116736
- PharmGKB
- PA449705
- PDBe Ligand
- FMT
- Wikipedia
- Formic_acid
- PDB Entries
- 1a5n / 1a5o / 1an5 / 1aob / 1aq6 / 1aus / 1axw / 1b93 / 1bdu / 1bid … show 1848 more
- MSDS
- Download (78.4 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 1 Completed Prevention Healthy Subjects (HS) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Kit; tablet; tablet, film coated Oral Capsule, gelatin coated; kit; tablet Oral Tablet, film coated Oral Tablet Oral Kit Oral Capsule, gelatin coated Oral Tablet, coated Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Liquid
- Experimental Properties
Property Value Source melting point (°C) 8.3 °C PhysProp boiling point (°C) 101 °C PhysProp water solubility 1E+006 mg/L (at 25 °C) RIDDICK,JA ET AL. (1986) logP -0.54 HANSCH,C ET AL. (1995) pKa 3.75 (at 25 °C) RIDDICK,JA ET AL. (1986) - Predicted Properties
Property Value Source Water Solubility 477.0 mg/mL ALOGPS logP -0.47 ALOGPS logP -0.27 Chemaxon logS 1.02 ALOGPS pKa (Strongest Acidic) 4.27 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 37.3 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 8.15 m3·mol-1 Chemaxon Polarizability 3.37 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9726 Blood Brain Barrier + 0.9652 Caco-2 permeable + 0.6096 P-glycoprotein substrate Non-substrate 0.8931 P-glycoprotein inhibitor I Non-inhibitor 0.9906 P-glycoprotein inhibitor II Non-inhibitor 0.9913 Renal organic cation transporter Non-inhibitor 0.9444 CYP450 2C9 substrate Non-substrate 0.8181 CYP450 2D6 substrate Non-substrate 0.9527 CYP450 3A4 substrate Non-substrate 0.8338 CYP450 1A2 substrate Non-inhibitor 0.9272 CYP450 2C9 inhibitor Non-inhibitor 0.9723 CYP450 2D6 inhibitor Non-inhibitor 0.9675 CYP450 2C19 inhibitor Non-inhibitor 0.9877 CYP450 3A4 inhibitor Non-inhibitor 0.9843 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9922 Ames test Non AMES toxic 0.9551 Carcinogenicity Carcinogens 0.6199 Biodegradation Ready biodegradable 0.9383 Rat acute toxicity 1.6531 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9799 hERG inhibition (predictor II) Non-inhibitor 0.9886
Spectra
- Mass Spec (NIST)
- Download (7.52 KB)
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 111.74964 predictedDeepCCS 1.0 (2019) [M-H]- 111.74964 predictedDeepCCS 1.0 (2019) [M+H]+ 113.581894 predictedDeepCCS 1.0 (2019) [M+H]+ 113.581894 predictedDeepCCS 1.0 (2019) [M+Na]+ 120.819695 predictedDeepCCS 1.0 (2019) [M+Na]+ 120.819695 predictedDeepCCS 1.0 (2019)
Targets
Build, predict & validate machine-learning models
Use our structured and evidence-based datasets to unlock newinsights and accelerate drug research.
Use our structured and evidence-based datasets to unlock new insights and accelerate drug research.
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Hydroxypyruvate isomerase activity
- Specific Function
- Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).
- Gene Name
- ygbM
- Uniprot ID
- Q46891
- Uniprot Name
- Putative hydroxypyruvate isomerase YgbM
- Molecular Weight
- 29216.725 Da
References
- Kind
- Protein
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen...
- Gene Name
- hemB
- Uniprot ID
- Q59643
- Uniprot Name
- Delta-aminolevulinic acid dehydratase
- Molecular Weight
- 37036.6 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Signal transducer activity
- Specific Function
- Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the a...
- Gene Name
- HMOX1
- Uniprot ID
- P09601
- Uniprot Name
- Heme oxygenase 1
- Molecular Weight
- 32818.345 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Ribonuclease a activity
- Specific Function
- Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.
- Gene Name
- RNASE1
- Uniprot ID
- P07998
- Uniprot Name
- Ribonuclease pancreatic
- Molecular Weight
- 17644.125 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- 3-phosphoshikimate 1-carboxyvinyltransferase activity
- Specific Function
- Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
- Gene Name
- aroA
- Uniprot ID
- P0A6D3
- Uniprot Name
- 3-phosphoshikimate 1-carboxyvinyltransferase
- Molecular Weight
- 46095.29 Da
References
- Kind
- Protein
- Organism
- Bacillus licheniformis
- Pharmacological action
- Unknown
- General Function
- Serine-type endopeptidase activity
- Specific Function
- Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides.
- Gene Name
- apr
- Uniprot ID
- P00780
- Uniprot Name
- Subtilisin Carlsberg
- Molecular Weight
- 38907.64 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- S100 protein binding
- Specific Function
- Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
- Gene Name
- FGF1
- Uniprot ID
- P05230
- Uniprot Name
- Fibroblast growth factor 1
- Molecular Weight
- 17459.58 Da
References
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activi...
- Gene Name
- def
- Uniprot ID
- P0A6K3
- Uniprot Name
- Peptide deformylase
- Molecular Weight
- 19328.23 Da
References
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Oxo-acid-lyase activity
- Specific Function
- Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutami...
- Gene Name
- pabB
- Uniprot ID
- P05041
- Uniprot Name
- Aminodeoxychorismate synthase component 1
- Molecular Weight
- 50969.07 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion in...
- Gene Name
- CA2
- Uniprot ID
- P00918
- Uniprot Name
- Carbonic anhydrase 2
- Molecular Weight
- 29245.895 Da
References
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Fmn binding
- Specific Function
- Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
- Gene Name
- pyrD
- Uniprot ID
- P0A7E1
- Uniprot Name
- Dihydroorotate dehydrogenase (quinone)
- Molecular Weight
- 36774.185 Da
References
- Kind
- Protein
- Organism
- Xanthobacter autotrophicus
- Pharmacological action
- Unknown
- General Function
- (s)-2-haloacid dehalogenase activity
- Specific Function
- Catalyzes the hydrolytic dehalogenation of small L-2-haloalkanoic acids to yield the corresponding D-2-hydroxyalkanoic acids. Active with 2-halogenated carboxylic acids and converts only the L-isom...
- Gene Name
- dhlB
- Uniprot ID
- Q60099
- Uniprot Name
- (S)-2-haloacid dehalogenase
- Molecular Weight
- 27469.15 Da
References
- Kind
- Protein
- Organism
- Salmonella typhimurium
- Pharmacological action
- Unknown
- General Function
- Penicillin binding
- Specific Function
- This is an oxacillin-hydrolyzing beta-lactamase.
- Gene Name
- bla
- Uniprot ID
- P0A1V8
- Uniprot Name
- Beta-lactamase OXA-2
- Molecular Weight
- 31685.78 Da
References
- Kind
- Protein
- Organism
- Proteus mirabilis
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
- Gene Name
- katA
- Uniprot ID
- P42321
- Uniprot Name
- Catalase
- Molecular Weight
- 55614.085 Da
References
- Kind
- Protein
- Organism
- Thermus aquaticus
- Pharmacological action
- Unknown
- General Function
- Gtpase activity
- Specific Function
- Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the r...
- Gene Name
- ffh
- Uniprot ID
- O07347
- Uniprot Name
- Signal recognition particle protein
- Molecular Weight
- 47355.705 Da
References
- Kind
- Protein
- Organism
- Streptomyces avidinii
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
- Gene Name
- Not Available
- Uniprot ID
- P22629
- Uniprot Name
- Streptavidin
- Molecular Weight
- 18833.61 Da
References
- Kind
- Protein
- Organism
- Shigella flexneri
- Pharmacological action
- Unknown
- General Function
- Methylglyoxal synthase activity
- Specific Function
- Not Available
- Gene Name
- mgsA
- Uniprot ID
- P0A733
- Uniprot Name
- Methylglyoxal synthase
- Molecular Weight
- 16918.435 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Transcription factor binding
- Specific Function
- Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi...
- Gene Name
- CTBP1
- Uniprot ID
- Q13363
- Uniprot Name
- C-terminal-binding protein 1
- Molecular Weight
- 47534.865 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- 6-phosphogluconolactonase activity
- Specific Function
- Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
- Gene Name
- pgl
- Uniprot ID
- Q9X0N8
- Uniprot Name
- 6-phosphogluconolactonase
- Molecular Weight
- 25324.955 Da
References
- Kind
- Protein
- Organism
- Mycobacterium tuberculosis
- Pharmacological action
- Unknown
- General Function
- May play a role in fatty acid biosynthesis.
- Specific Function
- Lyase activity
- Gene Name
- citE
- Uniprot ID
- P9WPE1
- Uniprot Name
- Citrate lyase subunit beta-like protein
- Molecular Weight
- 28885.39 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Protein serine/threonine kinase activity
- Specific Function
- Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interact...
- Gene Name
- CASK
- Uniprot ID
- O14936
- Uniprot Name
- Peripheral plasma membrane protein CASK
- Molecular Weight
- 105121.915 Da
- Kind
- Protein
- Organism
- Mycobacterium tuberculosis
- Pharmacological action
- Unknown
- General Function
- Essential for recycling GMP and indirectly, cGMP.
- Specific Function
- Adenylate kinase activity
- Gene Name
- gmk
- Uniprot ID
- P9WKE9
- Uniprot Name
- Guanylate kinase
- Molecular Weight
- 22095.065 Da
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Butyrate kinase activity
- Specific Function
- Not Available
- Gene Name
- buk2
- Uniprot ID
- Q9X278
- Uniprot Name
- Probable butyrate kinase 2
- Molecular Weight
- 42022.04 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Gamma-glutamylcyclotransferase activity
- Specific Function
- Contributes to degradation of proteins cross-linked by transglutaminases. Degrades the cross-link between a lysine and a glutamic acid residue from two proteins that have been cross-linked by trans...
- Gene Name
- GGACT
- Uniprot ID
- Q9BVM4
- Uniprot Name
- Gamma-glutamylaminecyclotransferase
- Molecular Weight
- 17328.44 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Calcium ion binding
- Specific Function
- In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.
- Gene Name
- PVALB
- Uniprot ID
- P20472
- Uniprot Name
- Parvalbumin alpha
- Molecular Weight
- 12058.635 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Acylphosphatase activity
- Specific Function
- Its physiological role is not yet clear.
- Gene Name
- ACYP2
- Uniprot ID
- P14621
- Uniprot Name
- Acylphosphatase-2
- Molecular Weight
- 11139.52 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Bacillus cereus (strain ATCC 14579 / DSM 31)
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q81C15
- Uniprot Name
- Uncharacterized protein
- Molecular Weight
- 12777.45 Da
- Kind
- Protein
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- Pharmacological action
- Unknown
- General Function
- Arginine n-succinyltransferase activity
- Specific Function
- Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. Also acts on L-ornithine.
- Gene Name
- astA
- Uniprot ID
- P80357
- Uniprot Name
- Arginine N-succinyltransferase subunit alpha
- Molecular Weight
- 36930.335 Da
- Kind
- Protein
- Organism
- Bacillus subtilis (strain 168)
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Not Available
- Gene Name
- yvyI
- Uniprot ID
- P39841
- Uniprot Name
- Putative mannose-6-phosphate isomerase YvyI
- Molecular Weight
- 35427.725 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Tetrahydrobiopterin binding
- Specific Function
- Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. P...
- Gene Name
- NOS1
- Uniprot ID
- P29475
- Uniprot Name
- Nitric oxide synthase, brain
- Molecular Weight
- 160969.095 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q9X0V0
- Uniprot Name
- Mannoside ABC transport system, sugar-binding protein
- Molecular Weight
- 64077.82 Da
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Hydrolyzes p-nitrophenyl phosphate (pNPP) in vitro. Involved in the swarming motility process.
- Gene Name
- ycdX
- Uniprot ID
- P75914
- Uniprot Name
- Probable phosphatase YcdX
- Molecular Weight
- 26890.25 Da
- Kind
- Protein
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- Pharmacological action
- Unknown
- General Function
- Isochorismatase activity
- Specific Function
- Not Available
- Gene Name
- phzD1
- Uniprot ID
- Q7DC80
- Uniprot Name
- Phenazine biosynthesis protein PhzD
- Molecular Weight
- 23195.32 Da
- Kind
- Protein
- Organism
- Bacillus subtilis (strain 168)
- Pharmacological action
- Unknown
- General Function
- Oxalate decarboxylase activity
- Specific Function
- Converts oxalate to formate and CO(2) in an O(2)-dependent reaction. Can also catalyze minor side reactions: oxalate oxidation to produce H(2)O(2), and oxalate-dependent, H(2)O(2)-independent dye o...
- Gene Name
- oxdC
- Uniprot ID
- O34714
- Uniprot Name
- Oxalate decarboxylase OxdC
- Molecular Weight
- 43565.77 Da
- Kind
- Protein
- Organism
- Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity
- Specific Function
- Not Available
- Gene Name
- actIII
- Uniprot ID
- P16544
- Uniprot Name
- Putative ketoacyl reductase
- Molecular Weight
- 27264.88 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Molybdopterin molybdotransferase activity
- Specific Function
- Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Ca...
- Gene Name
- GPHN
- Uniprot ID
- Q9NQX3
- Uniprot Name
- Gephyrin
- Molecular Weight
- 79747.635 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Bacillus cereus (strain ATCC 14579 / DSM 31)
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q81F54
- Uniprot Name
- Glyoxalase family protein
- Molecular Weight
- 16581.885 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Lipid binding
- Specific Function
- Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell...
- Gene Name
- CYTH2
- Uniprot ID
- Q99418
- Uniprot Name
- Cytohesin-2
- Molecular Weight
- 46545.725 Da
- Kind
- Protein
- Organism
- Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4)
- Pharmacological action
- Unknown
- General Function
- Ligase activity
- Specific Function
- Decarboxylase subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD).
- Gene Name
- gcdA
- Uniprot ID
- Q06700
- Uniprot Name
- Glutaconyl-CoA decarboxylase subunit alpha
- Molecular Weight
- 64346.32 Da
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Dna binding
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q9WXS0
- Uniprot Name
- Transcriptional regulator, IclR family
- Molecular Weight
- 28118.475 Da
- Kind
- Protein
- Organism
- Helicobacter pylori (strain ATCC 700392 / 26695)
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
- Gene Name
- katA
- Uniprot ID
- P77872
- Uniprot Name
- Catalase
- Molecular Weight
- 58628.85 Da
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q9X0F9
- Uniprot Name
- Putative L-rhamnose mutarotase
- Molecular Weight
- 13061.115 Da
- Kind
- Protein
- Organism
- Plasmodium falciparum
- Pharmacological action
- Unknown
- General Function
- Glutathione transferase activity
- Specific Function
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin I...
- Gene Name
- GST
- Uniprot ID
- Q8ILQ7
- Uniprot Name
- Glutathione S-transferase
- Molecular Weight
- 24788.9 Da
- Kind
- Protein
- Organism
- Trypanosoma cruzi
- Pharmacological action
- Unknown
- General Function
- Hypoxanthine phosphoribosyltransferase activity
- Specific Function
- Not Available
- Gene Name
- HGPRTase
- Uniprot ID
- Q27796
- Uniprot Name
- Hypoxanthine-guanine phosphoribosyltransferase
- Molecular Weight
- 25529.02 Da
- Kind
- Protein
- Organism
- Bacillus subtilis (strain 168)
- Pharmacological action
- Unknown
- General Function
- Glutaminase activity
- Specific Function
- Not Available
- Gene Name
- glsA1
- Uniprot ID
- O31465
- Uniprot Name
- Glutaminase 1
- Molecular Weight
- 36186.3 Da
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Glutaminase activity
- Specific Function
- Not Available
- Gene Name
- glsA1
- Uniprot ID
- P77454
- Uniprot Name
- Glutaminase 1
- Molecular Weight
- 32903.075 Da
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Molybdopterin synthase activity
- Specific Function
- Converts molybdopterin precursor Z to molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD.
- Gene Name
- moaE
- Uniprot ID
- P30749
- Uniprot Name
- Molybdopterin synthase catalytic subunit
- Molecular Weight
- 16980.955 Da
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Transaminase activity
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q9X0L5
- Uniprot Name
- Aminotransferase, putative
- Molecular Weight
- 47135.19 Da
- Kind
- Protein
- Organism
- Pasteurella haemolytica
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Gene Name
- fbpA
- Uniprot ID
- Q9Z4N6
- Uniprot Name
- Iron ABC transporter substrate-binding protein
- Molecular Weight
- 38023.085 Da
- Kind
- Protein
- Organism
- Thermus thermophilus
- Pharmacological action
- Unknown
- General Function
- Dna topoisomerase type ii (atp-hydrolyzing) activity
- Specific Function
- Not Available
- Gene Name
- gyrB
- Uniprot ID
- Q5SHZ4
- Uniprot Name
- DNA gyrase subunit B
- Molecular Weight
- 70536.815 Da
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Symporter activity
- Specific Function
- Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine...
- Gene Name
- SLC16A3
- Uniprot ID
- O15427
- Uniprot Name
- Monocarboxylate transporter 4
- Molecular Weight
- 49468.9 Da
References
- Manning Fox JE, Meredith D, Halestrap AP: Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol. 2000 Dec 1;529 Pt 2:285-93. [Article]
Drug created at June 13, 2005 13:24 / Updated at December 11, 2021 01:26