Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor

Accession Number

DBCAT003359

Description

Not Available

Drugs

Drug	Drug Description
Zidovudine	A dideoxynucleoside used in the treatment of HIV infection.
Stavudine	A dideoxynucleoside used in the treatment of HIV infection.
Lamivudine	A reverse transcriptase inhibitor used to treat HIV and hepatitis B infections.
Emtricitabine	A nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV.
Didanosine	A reverse transcriptase inhibitor used to treat HIV.
Abacavir	An antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV.
Tenofovir	A nucleotide analog indicated in the treatment of HIV infections.
Tenofovir disoproxil	A nucleotide analog reverse transcriptase inhibitor used in the treatment of Hepatitis B infection and used in the management of HIV-1 infection.
Tenofovir alafenamide	A nucleoside analog reverse transcriptase inhibitor used for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease.
Abacavir hydroxyacetate	Prurisol is under investigation for the treatment of Chronic Stable Plaque Psoriasis. Prurisol has been investigated for the treatment of Plaque Psoriasis.

Drugs & Drug Targets

Drug	Target	Type
Zidovudine	Serum albumin	carrier
Zidovudine	Cytochrome P450 2A6	enzyme
Zidovudine	Cytochrome P450 2C9	enzyme
Zidovudine	Cytochrome P450 3A4	enzyme
Zidovudine	Reverse transcriptase/RNaseH	target
Zidovudine	Solute carrier family 22 member 2	transporter
Zidovudine	Solute carrier family 22 member 6	transporter
Zidovudine	Solute carrier family 22 member 7	transporter
Zidovudine	Solute carrier family 22 member 8	transporter
Zidovudine	Solute carrier family 22 member 11	transporter
Zidovudine	Sodium/nucleoside cotransporter 1	transporter
Zidovudine	Equilibrative nucleoside transporter 2	transporter
Zidovudine	P-glycoprotein 1	transporter
Zidovudine	Multidrug resistance-associated protein 4	transporter
Zidovudine	Multidrug resistance-associated protein 5	transporter
Zidovudine	ATP-binding cassette sub-family G member 2	transporter
Zidovudine	Telomerase reverse transcriptase	target
Zidovudine	Thymidine kinase, cytosolic	enzyme
Zidovudine	UDP-glucuronosyltransferase 2B7	enzyme
Zidovudine	UDP-glucuronosyltransferase 1-1	enzyme
Stavudine	Solute carrier family 22 member 6	transporter
Stavudine	Reverse transcriptase/RNaseH	target
Stavudine	Sodium/nucleoside cotransporter 1	transporter
Stavudine	Serum albumin	carrier
Lamivudine	DNA	target
Lamivudine	Protein P	target
Lamivudine	Multidrug resistance-associated protein 1	transporter
Lamivudine	Solute carrier family 22 member 6	transporter
Lamivudine	ATP-binding cassette sub-family G member 2	transporter
Lamivudine	Reverse transcriptase/RNaseH	target
Lamivudine	Solute carrier family 22 member 1	transporter
Lamivudine	Solute carrier family 22 member 2	transporter
Lamivudine	Solute carrier family 22 member 3	transporter
Lamivudine	Deoxycytidine kinase	enzyme
Lamivudine	UMP-CMP kinase	enzyme
Lamivudine	Phosphoglycerate kinase 1	enzyme
Lamivudine	Nucleoside diphosphate kinase A	enzyme
Lamivudine	Nucleoside diphosphate kinase B	enzyme
Lamivudine	Choline-phosphate cytidylyltransferase A	enzyme
Lamivudine	Ethanolamine-phosphate cytidylyltransferase	enzyme
Lamivudine	P-glycoprotein 1	transporter
Lamivudine	Multidrug resistance-associated protein 4	transporter
Lamivudine	Canalicular multispecific organic anion transporter 2	transporter
Lamivudine	Canalicular multispecific organic anion transporter 1	transporter
Lamivudine	5'(3')-deoxyribonucleotidase, cytosolic type	enzyme
Lamivudine	Serum albumin	carrier
Emtricitabine	Reverse transcriptase/RNaseH	target
Emtricitabine	Deoxycytidine kinase	enzyme
Emtricitabine	Serum albumin	carrier
Emtricitabine	Multidrug and toxin extrusion protein 1	transporter
Didanosine	Solute carrier family 22 member 6	transporter
Didanosine	Purine nucleoside phosphorylase	target
Didanosine	Reverse transcriptase/RNaseH	target
Didanosine	Equilibrative nucleoside transporter 1	transporter
Didanosine	Equilibrative nucleoside transporter 2	transporter
Didanosine	Serum albumin	carrier
Abacavir	Alcohol dehydrogenase 6	enzyme
Abacavir	UDP-glucuronosyltransferase 1-1	enzyme
Abacavir	Reverse transcriptase/RNaseH	target
Abacavir	Adenosine kinase	enzyme
Abacavir	HLA class I histocompatibility antigen, B-57 alpha chain	target
Tenofovir	P-glycoprotein 1	transporter
Tenofovir	Solute carrier family 22 member 6	transporter
Tenofovir	Solute carrier family 22 member 8	transporter
Tenofovir	Multidrug resistance-associated protein 4	transporter
Tenofovir	Nucleoside diphosphate kinase A	enzyme
Tenofovir	Nucleoside diphosphate kinase B	enzyme
Tenofovir	Adenylate kinase isoenzyme 1	enzyme
Tenofovir	Adenylate kinase 2, mitochondrial	enzyme
Tenofovir	Reverse transcriptase/RNaseH	target
Tenofovir	Reverse transcriptase	target
Tenofovir	DNA polymerase	target
Tenofovir	Serum albumin	carrier
Tenofovir disoproxil	Reverse transcriptase/RNaseH	target
Tenofovir disoproxil	Solute carrier family 22 member 6	transporter
Tenofovir disoproxil	Solute carrier family 22 member 8	transporter
Tenofovir disoproxil	Multidrug resistance-associated protein 7	transporter
Tenofovir disoproxil	Multidrug resistance-associated protein 4	transporter
Tenofovir disoproxil	Canalicular multispecific organic anion transporter 1	transporter
Tenofovir disoproxil	Adenylate kinase 2, mitochondrial	enzyme
Tenofovir disoproxil	Adenylate kinase 4, mitochondrial	enzyme
Tenofovir disoproxil	P-glycoprotein 1	transporter
Tenofovir disoproxil	Nucleoside diphosphokinase	enzyme
Tenofovir disoproxil	Creatine Kinases	enzyme
Tenofovir disoproxil	DNA polymerase/reverse transcriptase	target
Tenofovir alafenamide	Reverse transcriptase/RNaseH	target
Tenofovir alafenamide	P-glycoprotein 1	transporter
Tenofovir alafenamide	Multidrug resistance-associated protein 4	transporter
Tenofovir alafenamide	Solute carrier family 22 member 6	transporter
Tenofovir alafenamide	Solute carrier family 22 member 8	transporter
Tenofovir alafenamide	Lysosomal protective protein	enzyme
Tenofovir alafenamide	Liver carboxylesterase 1	enzyme
Tenofovir alafenamide	ATP-binding cassette sub-family G member 2	transporter
Tenofovir alafenamide	Solute carrier organic anion transporter family member 1B1	transporter
Tenofovir alafenamide	Solute carrier organic anion transporter family member 1B3	transporter
Tenofovir alafenamide	Reverse transcriptase	target
Tenofovir alafenamide	DNA polymerase	target
Tenofovir alafenamide	Serum albumin	carrier
Tenofovir alafenamide	Cytochrome P450 3A4	enzyme
Tenofovir alafenamide	Adenylate kinase isoenzyme 1	enzyme
Tenofovir alafenamide	Adenylate kinase 2, mitochondrial	enzyme
Tenofovir alafenamide	Nucleoside diphosphate kinase A	enzyme
Tenofovir alafenamide	Nucleoside diphosphate kinase B	enzyme